Journal of International Oncology››2015,Vol. 42››Issue (1): 37-39.doi:10.3760/cma.j.issn.1673-422X.2015.01.009

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Mechanism research of Tbx3 gene in tumor progression

Shan Zezhi, Yan Xuebing, Tian Yuan, Jin Zhiming

  1. Department of General Surgery, Sixth People’s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China
  • Received:2014-06-03Revised:2014-07-11Online:2015-01-08Published:2015-01-07
  • Contact:Jin Zhiming E-mail:jzmgyp@aliyun.com

Abstract:As a member of Tbox family, Tbx3 (Tbox3) is widely expressed in multiple organs and involves in the development of breast, limb, heart, eye, lung and pancreas during embryonic development stage. Moreover, Tbx3 plays an important role in maintaining the embryonic stem cells. Recent studies show that Tbx3 can work as a transcription factor to participate in the initiation and progression of tumor by epithelialmesenchymal transition, induction tumor stemness and methylation. A better understanding of Tbx3 will provide new insights into genetic diagnosis and targeted treatment of tumor.

Key words:Neoplastic stem cells,Methylation,Tbx3,Epithelial-mesenchymal transition