Mechanism of breast cancer metastasis suppressor gene 1 inhibiting tumor metastasis

Abstract

Abstract:Breast cancer metastasis suppressor gene 1(BRMS1) significantly reduces the invasion and metastasis of cancer cells. BRMS1 gene expression is decreased or deleted in the cells of various malignant tumors. BRMS1 gene can inhibit tumor cells invasion and metastasis by means of regulating gene transcription and protein translation by phosphoinositide signaling and nuclear factor-κB (NF-κB) signaling pathways, repairing intercellular communication and interacting with the mSin3histone deacetylase (HDAC) complex, estrogen receptor and other proteins. BRMS1 gene may be a new target for the gene treatment of tumor metastasis.

Key words:Gene,neoplasm,Tumor metastasis,Breast cancer metastasis suppressor gene 1,Inhibiting effect

Mao Li, Cui Caiping, Zhang Jing, Zhou Ping. Mechanism of breast cancer metastasis suppressor gene 1 inhibiting tumor metastasis[J]. Journal of International Oncology, 2016, 43(8): 619-621.

References

［1］ Hedley BD, Vaidya KS, Phadke P, et al. BRMS1 suppresses breast cancer metastasis in multiple experimental models of metastasis by reducing solitary cell survival and inhibiting growth initiation［J］. Clin Exp Metastasis, 2008, 25(7): 727-740. DOI： 10.1007/s10585-008-9184-0. ［2］ Wu Y, Mcewen GD, Harihar S, et al. BRMS1 expression alters the ultrastructural, biomechanical and biochemical properties of MDA-MB-435 human breast carcinoma cells: an AFM and Raman microspectroscopy study［J］. Cancer Lett, 2010, 293(1): 82-91. DOI： 10.1016/j.canlet.2009.12.016. ［3］ Wu Y, Jiang W, Wang Y, et al. Breast cancer metastasis suppressor 1 regulates hepatocellular carcinoma cell apoptosis via suppressing osteopontin expression［J］. PLoS One, 2012, 7(8): e42976. DOI： 10.1371/journal.pone.0042976. ［4］ You J, He X, Ding H, et al. BRMS1 regulates apoptosis in nonsmall cell lung cancer cells［J］. Cell Biochem Biophys, 2015, 71(1): 465-472. DOI： 10.1007/s12013-014-0226-8. ［5］ Vaidya KS, Harihar S, Phadke PA, et al. Breast cancer metastasis suppressor-1 differentially modulates growth factor signaling［J］. J Biol Chem, 2008, 283(42): 28354-28360. DOI： 10.1074/jbc.M710068200. ［6］ Liu Y, Mayo MW, Xiao A, et al. Loss of BRMS1 promotes a mesenchymal phenotype through NF-κBdependent regulation of Twist1［J］. Mol Cell Biol, 2015, 35(1): 303-317. DOI： 10.1128/MCB.00869-14. ［7］ Mei P, Bai J, Shi M, et al. BRMS1 suppresses glioma progression by regulating invasion, migration and adhesion of glioma cells［J］. PLoS One, 2014, 9(5): e98544. DOI： 10.1371/journal.pone.0098544. ［8］ Xing WJ, Liao XH, Wang N, et al. MRTF-A and STAT3 promote MDA-MB-231 cell migration via hypermethylating BRSM1［J］. IUBMB Life, 2015, 67(3): 202-217. DOI： 10.1002/iub.1362. ［9］ Slipicevic A, Holm R, Emilsen E, et al. Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased diseasefree survival［J］. BMC Cancer, 2012, 12: 73. DOI： 10.1186/1471-2407-12-73. ［10］ Hurst DR. Metastasis suppression by BRMS1 associated with SIN3 chromatin remodeling complexes［J］. Cancer Metastasis Rev, 2012, 31(3/4): 641651. DOI: 10.1007/s10555-012-9363-y. ［11］ Gong C, Qu S, Lv XB, et al. BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10［J］. Nat Commun, 2014, 5: 5406. DOI： 10.1038/ncomms6406. ［12］ Roesley SN, Suryadinata R, Morrish E, et al. Cyclindependent kinasemediated phosphorylation of breast cancer metastasis suppressor 1 (BRMS1) affects cell migration［J］. Cell Cycle, 2016, 15(1): 137-151. DOI： 10.1080/15384101.2015.1121328. ［13］ Edmonds MD, Hurst DR, Vaidya KS, et al. Breast cancer metastasis suppressor 1 coordinately regulates metastasisassociated microRNA expression［J］. Int J Cancer, 2009, 125(8): 1778-1785. DOI： 10.1002/ijc.24616. ［14］ Bodenstine TM, Vaidya KS, Ismail A, et al. Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition［J］. Cancer Res, 2010, 70(23): 10002-10011. DOI： 10.1158/0008-5472.CAN-10-2606. ［15］ Ma H, Gollahon LS. ERα mediates estrogeninduced expression of the breast cancer metastasis suppressor gene BRMS1［J］. Int J Mol Sci, 2016, 17(2): 10. DOI： 10.3390/ijms17020158. ［16］ Wu J, Wang Y, Qiao X, et al. Cloning and characterization of a novel human BRMS1 transcript variant in hepatocellular carcinoma cells［J］. Cancer Lett, 2013, 337(2): 266-275. DOI： 10.1016/j.canlet.2013.04.030. ［17］ Kramer D, Schn M, Bayerlová M, et al. A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity［J］. Cell death disease, 2015, 6: e1634. DOI： 10.1038/cddis.2015.17. ［18］ Balgkouranidou I, Chimonidou M, Milaki G, et al. Breast cancer metastasis suppressor1 promoter methylation in cellfree DNA provides prognostic information in non-small cell lung cancer［J］. Br J Cancer, 2014, 110(8): 2054-2062. DOI： 10.1038/bjc.2014.104.

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