Abstract:ObjectiveTo determine the relationship between dietary fiber intake and risk of prostate cancer. MethodsElectronic databases including PubMed, EMBase, Cochrane library, China National Knowledge Internet (CNKI), Wanfang and CBM were searched to find eligible studies. Randomeffects relative risk (RR) and its corresponding 95%CI were used. Besides, randomeffects doseresponse analyses were also performed to clarify the doseresponse relations. ResultsTen studies, including five cohort studies and five casecontrol studies, were eligible and included in this Metaanalysis. The pooled RR of prostate cancer for the highest compared with the lowest dietary fiber intake was 0.87 (95%CI: 0.770.99, Z=2.10, P=0.035). In addition, pooled estimated data showed that risk of prostate cancer was significantly associated with soluble fiber (RR=0.78, 95%CI: 0.640.95, Z=2.45, P=0.014) and insoluble fiber (RR=0.65, 95%CI: 0.450.88, Z=2.79, P=0.005), but not with fruit, vegetable and cereal fiber intake. However, in doseresponse analysis, no significant association was reported （RR=0.996， 95%CI： 0.9891.002）. Sensitivity analysis showed that the overall results were relatively stable, and omission of any single study had little effect on the combined results. ConclusionDietary fiber intake is negative related to the risk of prostate cancer. Intake of dietary fiber is recommended to prevent prostate cancer. Considering the limitations of the included studies, more welldesigned prospective studies will be needed to confirm our findings.

Key words:Dietary fiber,Prostatic neoplasms,Metaanalysis