Journal of International Oncology››2017,Vol. 44››Issue (1): 6-10.doi:10.3760/cma.j.issn.1673-422X.2017.01.002

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Diagnostic value of combined detection of serum DKK1 and EB virus VCA-IgA for nasopharyngeal carcinoma

Xu Yiwei, Huang Lisheng, Guo Haipeng, Peng Yuhui

  1. Department of Clinical Laboratory, Cancer Hospital of Shantou University Medical College, Shantou 515041, China
  • Online:2017-01-08Published:2016-12-07
  • Contact:Peng Yuhui, Email: pengyuhui666@163.com E-mail:pengyuhui666@163.com
  • Supported by:

    Science and Technology Program of Guangdong Province (2013B021800250); Clinical Promotion Plan of Shantou University Medical College (201428)

Abstract:Objective To explore the diagnostic value of the combined detection of serum Dickkopf-1(DKK1) and EB viral capsid antigen immunoglobulin A (VCA-IgA) in patients with nasopharyngeal carcinoma (NPC). Methods Serum levels of DKK1 and VCA-IgA were measured by enzymelinked immunosorbent assay (ELISA) for the 80 patients with NPC and 65 normal controls. Receiver operating characteristic (ROC) curve was used to calculate the diagnostic value. Results The serum levels [M(QR)] of DKK1 in patients with NPC were significantly higher than those in normal controls [580.773(429.146)pg/mlvs. 316.174(252.965)pg/ml], with a significant difference (Z=4.846,P<0.000 1). ROC curves showed that the optimum diagnostic cutoff for serum DKK1 was 611.981 pg/ml, with an area under curve (AUC) of 0.734 (95%CI:0.654-0.815, 50.0% sensitivity, 96.9% specificity). Measurement of VCA-IgA demonstrated an AUC of 0.714 (95%CI:0.631-0.798, 47.5% sensitivity, 95.4% specificity). The combined detection of DKK1 and VCA-IgA demonstrated an AUC of 0.849 (95%CI:0.783-0.914, 76.3% sensitivity, 95.4% specificity). For patients with early-stage NPC, the detection effect of combined detection of DKK1 and VCA-IgA was much better than that in normal controls, with a significant difference (χ2=23.784,P<0.001). Conclusion Serum DKK1 has potential diagnostic value for NPC. Combined detection of DKK1 and VCA-IgA may aid the early diagnosis of NPC.

Key words:Nasopharyngeal neoplasms,Diagnosis,Dickkopf-1,EB viral capsid antigen immunoglo-bulin A