Journal of International Oncology››2017,Vol. 44››Issue (12): 911-913.doi:10.3760/cma.j.issn.1673-422X.2017.12.007

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Role of long non-coding RNA urothelial carcinoma associated antigen 1 as a competing endogenous RNA in the regulation of the initiation and progression of tumor

Gu Shuming, Xu Min.

  1. Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang 212000, China
  • Online:2017-12-08Published:2017-12-01
  • Contact:Xu Min, Email: peterxu1974@163.com E-mail: peterxu1974@163.com
  • Supported by:
    National Natural Science Foundation of China (81672402); "Six Ones Program"of High-level Health Talents of Jiangsu Province (LGY2016054)

Abstract:Long non-coding RNA urothelial carcinoma associated antigen 1 (UCA1) is highly expressed in multiple types of tumors, such as bladder cancer, breast cancer, colorectal cancer and so on. Recent studies show that UCA1 can interact with the microRNAs as a competing endogenous RNA (ceRNA), to indirectly regulate the expression of target genes, and then participates in the regulation of the initiation and progression of tumor. Therefore, using the mechanism of ceRNA to intervene the expression of UCA1 will provide new ideas for tumor treatment.

Key words:Neoplasms,Long non-coding RNA,Urothelial carcinoma associated antigen 1,Competing endogenous RNA