Journal of International Oncology››2019,Vol. 46››Issue (6): 378-381.doi:10.3760/cma.j.issn.1673-422X.2019.06.014

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Research progress on exosomederived noncoding RNAs in liquid biopsy of hepatocelluar carcinoma

Zhang Fangyong, Wu Fan

  1. Department of General Surgery, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, China
  • Online:2019-06-08Published:2019-07-11
  • Contact:Wu Fan, Email: wufan7911@ext.jnu.edu.cn E-mail:wufan7911@ext.jnu.edu.cn
  • Supported by:

    Natural Science Foundation of Guangdong Province of China (2014A030313654); Medical Scientific Research Foundation of Guangdong Province of China (A2018028); Science and Technology Planning Project of Guangzhou Municipal Bureau of China (201804010025)

Abstract:Exosomes contain ample non-coding RNAs, which mainly function as regulating gene expression and play key roles in the occurrence and development of hepatocellular carcinoma. Exosomal non-coding RNAs are expected to become a new biopsy marker for hepatocellular carcinoma, providing a new means for early diagnosis and early treatment of hepatocellular carcinoma.Although the clinical application of exosomal noncoding RNAs is still insufficient at present, exosomal noncoding RNAs will play an increasingly important role in the diagnosis, personalized treatment and prognosis evaluation of hepatocellular carcinoma with the deepening of research.

Key words:Liver neoplasms,Liquid biopsy,Exosomes,Non-coding RNA