Journal of International Oncology

Journal of International Oncology››2019,Vol. 46››Issue (9): 553-557.doi:10.3760/cma.j.issn.1673-422X.2019.09.009

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Research progress of non-coding RNA in gastric cancer

Xiao Chang, Xin Yan

  1. Laboratory of Gastrointestinal Tumor Pathology, Cancer Institute ＆ Laboratory of Tumor Pathology, General Surgery Institute, First Affiliated Hospital of China Medical University, Shenyang 110001, China
  • Received:2019-07-11Online:2019-09-08Published:2019-09-08
  • Contact:Xin Yan E-mail:yxin@cmu.edu.cn
  • Supported by:
    National Natural Science Foundation of China (81071650); Science and Technology Project of Liaoning Province of China (2013225585)

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Abstract:Non-coding RNA is a kind of RNA, without protein coding function, which plays an important role in the occurrence and development of tumors. Studies show that long noncoding RNA, circRNA and pseudogenes play tumorpromoting and antitumor effects in the occurrence and development of gastric cancer, which can regulate all kinds of malignant biological behaviors of gastric cancer such as cell proliferation, apoptosis, invasion and metastasis through internal competitive RNA (ceRNA) mechanism. In addition, studies show that small interfering RNA and Piwiinteracting RNA may also be related to the occurrence and development of gastric cancer.

Key words:Stomach neoplasms,Non-coding RNA