Journal of International Oncology

Journal of International Oncology››2019,Vol. 46››Issue (9): 558-561.doi:10.3760/cma.j.issn.1673-422X.2019.09.010

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Advancement of the risk prediction of hepatocellular carcinoma in patients with chronic hepatitis B virus infection

Chen Wenjun1, Wang Junjuan2, Qi Jianni3, Dong Chonghai1, Qin Chengyong3

  1. 1Department of Gastroenterology, Affiliated Weihai Second Municipal Hospital of Qingdao University, Weihai 264200, China;2Department of Child Rehabilition, Affiliated Weihai Second Municipal Hospital of Qingdao University, Weihai 264200, China;3Department of Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2019-04-30Online:2019-09-08Published:2019-09-08
  • Contact:Chen Wenjun E-mail:chwhju@163.com

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Abstract:It is of important significant to predict the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus infection in clinic. Various risks scoring systems can achieve better prediction effect by integrating a variety of risk factors, but they still need to be perfected. Recent researches have found that some genotypes and genetic variations are associated with the occurrence of HCC and they can indicate the tumorigenesis of HCC. Some known or newly discovered indicators such as WFA+M2BP can be used to predict the occurrence of HCC independently or jointly. With the development of research, more genes, indicators as well as newly built scoring system will be utilized to predict the occurrence of HCC in clinic.

Key words:Hepatitis B virus,Infection,Carcinoma, hepatocellular,Risk assessment