Journal of International Oncology››2020,Vol. 47››Issue (2): 119-122.doi:10.3760/cma.j.issn.1673-422X.2020.02.012

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Advances of Krüppel-like factors in hepatocellular carcinoma

Zhao Chuanxi1, Zhu Tingting1, Liu Mingguo2, Cao Lili1,3()

  1. 1 Department of Oncology, First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250014, China
    2 Second Department of Internal Medicine, Yuncheng Chengxin Hospital of Heze City of Shandong Province, Yuncheng 274700, China
    3 Shandong Provincial Key Laboratory for Rheumatic Immunity Disease and Translational Medicine, First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Jinan 250014, China
  • Received:2019-12-13Revised:2020-01-13Online:2020-02-08Published:2020-05-27
  • Contact:Cao Lili E-mail:cllly22@163.com

Abstract:

Krüppel-like factors (KLFs) play extremely important roles in genesis and development of tumors. Simultaneously, KLFs have been proven to affect the proliferation, differentiation and migration of hepatocellular carcinoma cells. Nine members in the KLFs family (KLF2, KLF4, KLF5, KLF6, KLF8, KLF9, KLF10, KLF14 and KLF17) are involved in the occurrence and development of hepatocellular carcinoma in various ways as an oncogene and tumor suppressor gene. Therefore, the KLFs family will hopefully become biological therapeutic targets for hepatocellular carcinoma.

Key words:Liver neoplasms,Genes, tumor suppressor,Oncogene,Krüppel-like factors