Abstract:Yin-Yang1(YY1), as a ubiquitous nuclear transcription factor with double transcriptional activity in eukaryotic cells, regulates many genes transcription andplays an important role inthe cellule biological processes. Overexpression of YY1 is found in several tumor types recently, and may play a role in tumor development and progression by regulating oncogenes, tumor suppressor genes, angiogenesis related factors, as well as apoptosis. YY1 may become a new kind of tumor markers, is conducive toestimatethe prognosis of patients with tumor and gain important breakthrough in cancer targeted therapy.

Key words:font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt">Gene expression regulation,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt">Neoplasms,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt">YY1 transcription factor