Abstract:Amplified in breast cancer 1 (AIB1) plays an important role in the process of gene expression and regulation by combining with nuclear receptor. Aberrant expression of AIB1 has been detected in different types of caners, such as breast cancer, colorectal carcinoma, gastric carcinoma, esophageal carcinoma, lung cancer, etc. The study of the potential role of AIB1 in the pathogenesis and prognosis will improve our general acknowledge of carcinogenesis. AIB1 may become a new prognostic marker as well as a new therapeutic target.