Journal of International Oncology››2012,Vol. 39››Issue (7): 483-485.

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Tumor multidrug resistance and apoptosis evasion

SUN Fei, QING Chen

  1. School of Pharmacy & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical College, Kunming 650500, China
  • Online:2012-08-06Published:2012-08-06
  • Contact:QING Chen, E-mail: qingchenhh@yeah.net E-mail:E-mail:qingchenhh@yeah.net

Abstract:Most anticancer drugs inhibit tumor cell growth by inducing apoptosis. Apoptosis-evasion, also enhancement of antiapoptosis ability (e.g. anti-apoptosis related genes over-expression or pro-apoptotic related genes loss, etc.) may lead to tumor cell multidrug resistance. Many researches show that apoptosis-evasion is one of the important factors resulting in tumor multidrug resistance.

Key words:Drug resistance,neoplasm,Apoptosis,Tumor escape