Abstract:This paper summarizes the new progress of the research of the targeted microbubble ultrasound contrast agents and ultrasound molecular imaging in tumor angiogenesis. There are two constructing methods of targeted microbubble ultrasound contrast agents. Targeted new blood vessels microbubble unltrasound contrast agents are mainly divided into the connection of alpha (V) beta3 antibody, αVβ3 integration antibody and connecting VEGFR2. The quantitative analysis of targeted microbubble adhering to tumor target and the evaluation of the correlation between targeted microbubble adhering to tumor neovascular endothelial cell and tumor local pathological microvessel density suggest that ultrasound molecular imaging can be noninvasive, quick, repeated, dynamic and quantitative evaluate tumor angiogenesis and indirectly reflect the malignant tumor tissue proliferation activity and its biological characteristics.

Key words:Contrast media,Neovascularization,pathologic,Ultrasound molecular imaging