Journal of International Oncology››2012,Vol. 39››Issue (7): 541-544.

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Role of Numb in tumors

WANG Chao, ZHANG Chu-Yao, FENG Wei-Wei

  1. Department of Gynecology and Obstetrics, Obstetrics & Gynecology Hospital of Fudan University, Shanghai 200011, China
  • Online:2012-08-06Published:2012-08-06
  • Contact:FENG Wei-wei, E-mail: jingsakura@gmail.com E-mail:jingsakura@gmail.com

Abstract:Numb, one of the important cell fate determinants, plays a key role in regulation of nerve system development, and it is closely related to the occurrence of tumors. It is proven that Numb is implicated in the processes of occurrence, invasion and metastasis of tumors through regulating the way of cell division, cell polarity, epithelialmesenchymal transitions and several signal pathways, e.g., Notch, Hh, p53. The expression levels of Numb in cells are related to the malignant degree and prognosis of tumors. It is vital to explore the role of Numb in tumors for treating tumors at the standpoint of Numb.

Key words:Neoplasms,Cell Division,Numb protein