Abstract:Neoadjuvant systemic therapy for breast cancer patients means systemic treatments before operations.Combination chemotherapy, endocrine therapy and targeted therapy before operation can degrade the tumor staging and increase the breast-conserving rates. Neoadjuvant chemotherapy has been accepted as one of the standard therapies for patients with locally advanced breast cancers.In the neoadjuvant setting, the studies about the use of aromatase inhibitors and trastuzumab in selected patients have also made great progress.

Key words:Breast neoplasms,Neoadjuvant therapy,Drug therapy,Endocrine therapy,Targeted therapy