Advance of treatment in hormone refractory prostate cancer

Abstract

Abstract:Treatment with docetaxel and prednisone every 3 weeks is preferred in hormone refractory prostate cancer. In recent years, a number of clinical trials are held to assess the efficacy of docetaxelbased regimens combined with antiangiogenesis agents, firstline treatment of androgen ablation, and salvage therapy after chemotherapy failure with docetaxel. For hormone refractory prostate cancer, abiraterone can be used as the first choice, while, enzalutamide can be used as another endocrine therapy for patients who tolerate with docetaxel. However, chemotherapy combined with targeted drugs still cannot challenge the firstline treatment status of docetaxel plus prednisone.

Key words:Prostatic neoplasms,Drug therapy,Drug resistance, neoplasm,Androgen antagonists

Wang Ying, Li Xuyuan, Lin Yingcheng. Advance of treatment in hormone refractory prostate cancer[J]. Journal of International Oncology, 2014, 41(1): 56-59.

References

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