Journal of International Oncology››2014,Vol. 41››Issue (2): 96-99.doi:10.3760/cma.j.issn.1673-422X.2014.02.006

Previous ArticlesNext Articles

Anti-tumor mechanisms of oleanolic acid

Huang Xuexiang, Yang Yu

  1. Department of Oncology, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
  • Received:2013-09-24Revised:2013-12-04Online:2014-02-08Published:2014-01-26
  • Contact:Yang Yu E-mail:yangy@medmail.com.cn

Abstract:Oleanolic acid (OA), a pentacyclic triterpenoid, possesses a variety of pharmacological activities, such as hepatoprotective effect, antiinflammatory, enhancing immunity. Recently, many studies show that OA has inhibitory effects on the growth of many tumors and is a kind of potential antitumor drug. Its antitumor mechanisms mainly include regulating signaling pathway, arresting cell cycle, inducing apoptosis, antiangiogenesis, inhibiting tumor invasion and so on.

Key words:Oleanolic acid,Antineoplastic agents,Apoptosis