Journal of International Oncology››2014,Vol. 41››Issue (8): 592-594.doi:10.3760/cma.j.issn.1673-422X.2014.08.011

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Advances of anaplastic lymphoma kinase in non-small cell lung cancer

Fang Shu, Pan Zhifeng

  1. Third Department of Medicine, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Ji′nan 250117, China
  • Received:2014-04-14Revised:2014-05-14Online:2014-08-15Published:2014-08-14
  • Contact:Pan Zhifeng E-mail:18653199172@163.com

Abstract:Targeted therapy is the most prospective part of the research related to the treatment of nonsmall cell lung cancer (NSCLC). After epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) gene is expected to become a new target in the treatment of NSCLC. Moreover, several related researches suggest that ALK inhibitor (crizotinib) is effective for treatment of ALKrearranged NSCLC. Therefore, it is important to review the detection method of ALK gene, clinicopathologic features and the research progress of ALK inhibitor for the individual treatment of NSCLC.

Key words:Carcinoma, non-small-cell lung,Anaplastic lymphoma kinase,Molecular targeted therapy