Journal of International Oncology››2016,Vol. 43››Issue (11): 861-864.doi:10.3760/cma.j.issn.1673-422X.2016.11.016

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Chemotherapy drug resistance mechanisms of hepatocellular carcinoma to arsenic trioxide

Chen Yaoting, Hu Xiaojun, Li Dan, Shan Hong

  1. Center for Interventional Medicine, Fifth Affiliated Hospital of Sun Yatsen University, Zhuhai 519000, China; Department of Interventional Radiology, Sun Yatsen Memorial Hospital, Sun Yatsen University, Guangzhou 510120, China
  • Received:2016-03-28Online:2016-11-08Published:2016-11-02
  • Contact:Shan Hong E-mail:shanhong@mail.sysu.edu.cn
  • Supported by:

    National Natural Science Foundation of China (81430041)

Abstract:Many studies have proven that arsenic trioxide (As2O3) as a single agent is not effective against hepatocellular carcinoma (HCC). Many scholars believe that chemotherapy drug resistance of HCC to As2O3 is the most important reason. The underlying drug resistance mechanism of HCC cells to As2O3 remains unclear. Studies show that potential mechanism may be tightly associated with As2O3 pharmacokinetics and properties of HCC tissues and complex molecular biology.

Key words:Liver neoplasms,Arsenicals,Drug resistance, neoplasm,Molecular targeted therapy