Immunosenescence and its role in cancer

Abstract

Abstract:Immunosenescence is a biological process featured by the structural and functional decline of immunity in ageing people, which favors the carcinogenesis by rendering the body′s immune surveillance and tumor escape. Decreasing clearance of tumor cells by macrophages and natural killer cell reflects the immunosenescence of innate immune, also, the tumor antigen presentation ability of dendritic cell is decreased. While, the decline of the CD8+ T cells cytotoxic effect and the secretion of tumor growth factor accounts for the immunosenescence of adaptive immunity. Intervention of immunosenescence may produce the novelty ideas of prevention and treatment of cancer.

Key words:Immunity,Aging,Neoplasms,Immunity, natural,Immunity, maternallyacquired,Tumor escape

TIAN Jian-Hui, LUO Bin, LIU Jia-Xiang. Immunosenescence and its role in cancer[J]. Journal of International Oncology, 2016, 43(2): 122-.

References

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