Reversal of Pglycoproteinmediated multidrug resistance mechanism by curcumin

Abstract

Abstract:Multidrug resistance (MDR) is one of the important reasons for the failure of clinical anticancer drugs, involving multiple mechanisms. Among them, the classical MDR mechanism mediated by Pglycoprotein (Pgp) is closely related to the formation of MDR, which can excrete intracellular chemotherapeutic drugs through the "drug pump" effect and significantly reduce the therapeutic effect. Curcumin is mainly extracted from the underground rhizome of Chinese medicine turmeric, with a wide range of pharmacological activity. Recent studies have found that curcumin also has a role in reversing the MDR of the tumor, by inhibiting both Pgp function and expression, and this process involves a variety of signal paths.

Key words:Curcumin,P-glycoprotein,Multidrug resistance,Signal path

Liu Lan, Zhang Zhimin, Peng Wenmiao, Fu Hongxing, Rao Zhiguo. Reversal of Pglycoproteinmediated multidrug resistance mechanism by curcumin[J]. Journal of International Oncology, 2017, 44(10): 758-761.

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