Zinc finger proteins and digestive system cancers

Abstract

Abstract:

Zinc finger proteins (ZNFs) belong to the largest transcriptional factor family in human genome. ZNFs are widely involved in the development and progression of digestive system cancers by promoting or inhibiting carcinogenesis. Studies have shown that the abnormal expressions of various ZNFs are closely related to the clinicopathologic features and prognosis of patients with digestive system cancers, including gastric cancer, liver cancer, colorectal cancer and pancreatic cancer. Exploring the underlying mechanism of ZNFs will help to provide new targets for clinical treatment of digestive system cancers.

Key words:Stomach neoplasms,Carcinoma, hepatocellular,Colorectal neoplasms,Pancreatic neoplasms,Zinc finger proteins

Tian Chunfang, Sha Dan. Zinc finger proteins and digestive system cancers[J]. Journal of International Oncology, 2020, 47(2): 115-118.

References31

[1]	Bray F, Ferlay J, Soerjomataram I , et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018,68(6):394-424. DOI: 10.3322/caac.21492. doi:10.3322/caac.v68.6
[2]	Feng RM, Zong YN, Cao SM , et al. Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?[J]. Cancer Commun (Lond), 2019,39(1):22. DOI: 10.1186/s40880-019-0368-6.
[3]	Frankel AD, Pabo CO . Fingering too many proteins[J]. Cell, 1988,53(5):675. DOI: 10.1016/0092-8674(88)90083-9. doi:10.1016/0092-8674(88)90083-9
[4]	Braschi B, Denny P, Gray K , et al. Genenames.org: the HGNC and VGNC resources in 2019[J]. Nucleic Acids Res, 2019,47(D1):D786-D792. DOI: 10.1093/nar/gky930. doi:10.1093/nar/gky930
[5]	Cassandri M, Smirnov A, Novelli F , et al. Zinc-finger proteins in health and disease[J]. Cell Death Discov, 2017,3:17071. DOI: 10.1038/cddiscovery.2017.71. doi:10.1038/cddiscovery.2017.71
[6]	Eom KS, Cheong JS, Lee SJ . Structural analyses of Zinc finger domains for specific interactions with DNA[J]. J Microbiol Biotechnol, 2016,26(12):2019-2029. DOI: 10.4014/jmb.1609.09021. doi:10.4014/jmb.1609.09021
[7]	Schmitges FW, Radovani E, Najafabadi HS , et al. Multiparameter functional diversity of human C2H2 zinc finger proteins[J]. Genome Res, 2016,26(12):1742-1752. DOI: 10.1101/gr.209643.116.
[8]	Jen J, Wang YC . Zinc finger proteins in cancer progression[J]. J Biomed Sci, 2016,23(1):53. DOI: 10.1186/s12929-016-0269-9.
[9]	Liao Z, Wang X, Chen X , et al. Prediction and identification of Kruppel-like transcription factors by machine learning method[J]. Comb Chem High Throughput Screen, 2017,20(7):594-602. DOI: 10.2174/1386207320666170314094951.
[10]	Zhu M, Zhang N, Lu X , et al. Negative regulation of Kruppel-like factor 4 on microRNA-106a at upstream transcriptional level and the role in gastric cancer metastasis[J]. Dig Dis Sci, 2018,63(10):2604-2616. DOI: 10.1007/s10620-018-5143-z.
[11]	Hashimoto I, Nagata T, Sekine S , et al. Prognostic significance of KLF4 expression in gastric cancer[J]. Oncol Lett, 2017,13(2):819-826. DOI: 10.3892/ol.2016.5499.
[12]	Zhou T, Chen S, Mao X . miR-145-5p affects the differentiation of gastric cancer by targeting KLF5 directly[J]. J Cell Physiol, 2019,234(5):7634-7644. DOI: 10.1002/jcp.27525.
[13]	Tan B, Li Y, Zhao Q , et al. ZNF139 increases multidrug resistance in gastric cancer cells by inhibiting miR-185[J]. Biosci Rep, 2018, 38(5): pii: BSR20181023. DOI: 10.1042/BSR20181023.
[14]	Nie H, Mu J, Wang J , et al. miR1955p regulates multidrug resistance of gastric cancer cells via targeting ZNF139[J]. Oncol Rep, 2018,40(3):1370-1378. DOI: 10.3892/or.2018.6524.
[15]	Cao L, Wang S, Zhang Y , et al. Zinc-finger protein 471 suppresses gastric cancer through transcriptionally repressing downstream oncogenic PLS3 and TFAP2A[J]. Oncogene, 2018,37(26):3601-3616. DOI: 10.1038/s41388-018-0220-5.
[16]	Chockley PJ, Keshamouni VG . Immunological consequences of epithelial-mesenchymal transition in tumor progression[J]. J Immunol, 2016,197(3):691-698. DOI: 10.4049/jimmunol.1600458.
[17]	Wang X, Hou Q, Zhou X . LAMA4 expression is activated by zinc finger E-box-binding homeobox 1 and independently predicts poor overall survival in gastric cancer[J]. Oncol Rep, 2018,40(3):1725-1733. DOI: 10.3892/or.2018.6564.
[18]	Geng DM, Kan XM, Zhang WW . Effect of ZEB2 silencing on cisplatin resistance in gastric cancer[J]. Eur Rev Med Pharmacol Sci, 2017,21(8):1746-1752.
[19]	Chen H, Lu W, Huang C , et al. Prognostic significance of ZEB1 and ZEB2 in digestive cancers: a cohort-based analysis and secondary analysis[J]. Oncotarget, 2017,8(19):31435-31448. DOI: 10.18632/oncotarget.15634.
[20]	Li GQ, He Q, Yang L , et al. Clinical significance of myeloid Zinc finger 1 expression in the progression of gastric tumourigenesis[J]. Cell Physiol Biochem, 2017,44(3):1242-1250. DOI: 10.1159/000485454.
[21]	Hui HX, Hu ZW, Jiang C , et al. ZNF418 overexpression protects against gastric carcinoma and prompts a good prognosis[J]. Onco Targets Ther, 2018,11:2763-2770. DOI: 10.2147/OTT.S160802.
[22]	Dai C, Dong Q, Lu Q , et al. Prognostic value of Zinc-finger protein X-linked in patients with solid tumors[J]. Minerva Chir, 2017,72(1):81-88. DOI: 10.23736/S0026-4733.16.07198-4.
[23]	Wang C, Fu SY, Wang MD , et al. Zinc finger protein X-linked promotes expansion of EpCAM⁺cancer stem-like cells in hepatocellular carcinoma[J]. Mol Oncol, 2017,11(5):455-469. DOI: 10.1002/1878-0261.12036.
[24]	Pang J, Li Z, Wang G , et al. miR-214-5p targets KLF5 and suppresses proliferation of human hepatocellular carcinoma cells[J]. J Cell Biochem, 2018. DOI: 10.1002/jcb.27498.
[25]	Guo C, Ma J, Deng G , et al. ZEB1 promotes oxaliplatin resistance through the induction of epithelial-mesenchymal transition in colon cancer cells[J]. J Cancer, 2017,8(17):3555-3566. DOI: 10.7150/jca.20952.
[26]	Li MZ, Wang JJ, Yang SB , et al. ZEB2 promotes tumor metastasis and correlates with poor prognosis of human colorectal cancer[J]. Am J Transl Res, 2017,9(6):2838-2851.
[27]	Yan X, Shan Z, Yan L , et al. High expression of Zinc-finger protein X-linked promotes tumor growth and predicts a poor outcome for stage Ⅱ/Ⅲ colorectal cancer patients[J]. Oncotarget, 2016,7(15):19680-19692. DOI: 10.18632/oncotarget.7547.
[28]	Xiang S, Xiang T, Xiao Q , et al. Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/β-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer[J]. Int J Oncol, 2017,51(3):801-811. DOI: 10.3892/ijo.2017.4064.
[29]	Xu WY, Hu QS, Qin Y , et al. Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer[J]. World J Gastroenterol, 2018,24(43):4893-4905. DOI: 10.3748/wjg.v24.i43.4893.
[30]	Song S, Yu W, Lin S , et al. LncRNA ADPGK-AS1 promotes pancreatic cancer progression through activating ZEB1-mediated epithelial-mesenchymal transition[J]. Cancer Biol Ther, 2018,19(7):573-583. DOI: 10.1080/15384047.2018.1423912.
[31]	Song X, Zhu M, Zhang F , et al. ZFX promotes proliferation and metastasis of pancreatic cancer cells via the MAPK pathway[J]. Cell Physiol Biochem, 2018,48(1):274-284. DOI: 10.1159/000491727.