Journal of International Oncology››2022,Vol. 49››Issue (6): 376-379.doi:10.3760/cma.j.cn371439-20211227-00072
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Received:2021-12-27Revised:2022-01-15Online:2022-06-08Published:2022-06-30
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| 患者类别 | CR | PR | SD | PD | 客观缓解 | 疾病控制 |
|---|---|---|---|---|---|---|
| EGFR突变类型 | ||||||
| 19del（n=19） | 0 | 16 | 3 | 0 | 16 | 19 |
| L858R（n=14） | 0 | 12 | 2 | 0 | 12 | 14 |
| L861Q（n=2） | 0 | 2 | 0 | 0 | 2 | 2 |
| 临床分期 | ||||||
| ⅢB~ⅢC期（n=10） | 0 | 10 | 0 | 0 | 10 | 10 |
| Ⅳ期（n=25） | 0 | 20 | 5 | 0 | 20 | 25 |
| ECOG评分 | ||||||
| 0~1分（n=20） | 0 | 18 | 2 | 0 | 18 | 20 |
| 2分（n=15） | 0 | 12 | 3 | 0 | 12 | 15 |
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| 不良反应 | 0~5级 | ≥3级 |
|---|---|---|
| 皮疹 | 16（44.4） | 0（0） |
| 食欲下降 | 15（42.9） | 0（0） |
| 贫血 | 13（37.1） | 0（0） |
| 呕吐 | 8（22.9） | 0（0） |
| 腹泻 | 5（14.3） | 1（2.9） |
| 疲乏 | 8（22.9） | 0（0） |
| 口腔黏膜炎 | 2（5.7） | 0（0） |
| 血压升高 | 2（5.7） | 0（0） |
| 鼻出血 | 2（5.7） | 0（0） |
| 丙氨酸氨基转移酶升高 | 12（34.3） | 1（2.9） |
| 粒细胞减少 | 4（11.4） | 1（2.9） |
| 蛋白尿 | 1（2.9） | 0（0） |
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