Journal of International Oncology››2022,Vol. 49››Issue (7): 441-443.doi:10.3760/cma.j.cn371439-20211215-00084
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Received:2021-12-15Revised:2022-03-27Online:2022-07-08Published:2022-09-19
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| 临床病理特征 | 例数 | 构成比（%） |
|---|---|---|
| 性别 | ||
| 男性 | 30 | 63.8 |
| 女性 | 17 | 36.2 |
| ECOG评分（分） | ||
| 1 | 8 | 17.0 |
| 2 | 39 | 83.0 |
| 吸烟史 | ||
| 有 | 29 | 61.7 |
| 无 | 18 | 38.3 |
| 一线化疗 | ||
| 单药化疗 | 9 | 19.1 |
| 含铂的双药化疗 | 38 | 80.8 |
| 病理类型 | ||
| 鳞状细胞癌 | 40 | 85.1 |
| 腺癌 | 7 | 14.9 |
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| 不良反应 | 1~2级 | 3~4级 |
|---|---|---|
| 白细胞减少 | 25（53.2） | 1（2.1） |
| 血小板减少 | 8（17.0） | 0（0） |
| 贫血 | 7（14.9） | 0（0） |
| 恶心 | 19（40.4） | 0（0） |
| 呕吐 | 11（23.4） | 0（0） |
| 乏力 | 31（66.0） | 0（0） |
| 腹泻 | 3（6.4） | 0（0） |
| 黏膜炎 | 5（10.6） | 0（0） |
| 末梢神经毒性 | 8（17.0） | 0（0） |
| [1] | Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2021[J]. CA Cancer J Clin, 2021, 71(1): 7-33. DOI: 10.3322/caac.21654. doi:10.3322/caac.21654 |
| [2] | Browder T, Butterfield CE, Kräling BM, et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer[J]. Cancer Res, 2000, 60(7): 1878-1886. pmid:10766175 |
| [3] | Romiti A, Falcone R, Roberto M, et al. Current achievements and future perspectives of metronomic chemotherapy[J]. Invest New Drugs, 2017, 35(3): 359-374. DOI: 10.1007/s10637-016-0408-x. doi:10.1007/s10637-016-0408-x |
| [4] | Liu CT, Hsieh MC, Su YL, et al. Metronomic vinorelbine is an excellent and safe treatment for advanced breast cancer: a retrospective, observational study[J]. J Cancer, 2021, 12(17): 5355-5364. DOI: 10.7150/jca.60682. doi:10.7150/jca.60682 |
| [5] | Xu K, Liu T, Zhang J, et al. The efficacy and toxicity of metronomic oral vinorelbine monotherapy in patients with non-small cell lung cancer: a meta-analysis[J]. Int J Clin Oncol, 2020, 25(9): 1624-1634. DOI: 10.1007/s10147-020-01707-9. doi:10.1007/s10147-020-01707-9 |
| [6] | SEER. Cancer stat facts: lung and bronchus cancer[R]. Bethesda: National Cancer Institute, 2019. |
| [7] | Abbasi J. Older patients (Still) left out of cancer clinical trials[J]. JAMA, 2019, 322(18): 1751-1753. DOI: 10.1001/jama.2019.17016. doi:10.1001/jama.2019.17016 |
| [8] | 祝情情, 谢超, 宋宝, 等. 节拍化疗在晚期非小细胞肺癌治疗中的应用[J]. 国际肿瘤学杂志, 2019, 46(6): 374-377. DOI: 10.3760/cma.j.issn.1673-422X.2019.06.013. doi:10.3760/cma.j.issn.1673-422X.2019.06.013 |
| [9] | 林金兰, 郭天兴, 潘小杰, 等. 长春瑞滨软胶囊单药节拍化疗一线治疗老年非小细胞肺癌临床疗效观察[J]. 肿瘤防治研究, 2018, 45(11): 909-912. DOI: 10.3971/j.issn.1000-8578.2018.18.0841. doi:10.3971/j.issn.1000-8578.2018.18.0841 |
| [10] | Camerini A, Morabito A, Montanino A, et al. Metronomic oral vinorelbine in previously untreated advanced non-small-cell lung cancer patients unfit for platinum-based chemotherapy: results of the randomized phase Ⅱ Tempo Lung trial[J]. ESMO Open, 2021, 6(2): 100051. DOI: 10.1016/j.esmoop.2021.100051. doi:10.1016/j.esmoop.2021.100051 |
| [11] | Pasini F, Barile C, Caruso D, et al. Oral metronomic vinorelbine (OMV) in elderly or pretreated patients with advanced non small cell lung cancer: outcome and pharmacokinetics in the real world[J]. Invest New Drugs, 2018, 36(5): 927-932. DOI: 10.1007/s10637-018-0631-8. doi:10.1007/s10637-018-0631-8 |
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