Research progress of HGF/c-MET signaling pathway inhibitors in antipancreatic cancer

Abstract

Qiao Yinbiao, Yang Bo. Research progress of HGF/c-MET signaling pathway inhibitors in antipancreatic cancer[J]. Journal of International Oncology, 2017, 44(4): 304-306.

［1］ Nones K, Waddell N, Song S, et al. Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and Met signaling［J］. Int J Cancer, 2014, 135(5): 1110-1118. DOI: 10.1002/ijc.28765. ［2］ Pothula SP, Xu ZH, Goldstein D, et al. Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer［J］. Br J Cancer, 2016, 114(3): 269-280. DOI: 10.1038/bjc.2015.478. ［3］ Delitto D, Vertes-George E, Hughes SJ, et al. c-Met signaling in the development of tumorigenesis and chemoresistance: potential applications in pancreatic cancer［J］. World J Gastroenterol, 2014, 20(26): 8458-8470. DOI: 10.3748/wjg.v20.i26.8458. ［4］ Huang C, Qiu ZJ, Wang LW, et al. A novel FoxM1-Caveolin signaling pathway promotes pancreatic cancer invasion and metastasis［J］. Cancer Res, 2012, 72(3): 655-665. DOI: 10.1158/0008-5472.CAN-11-3102. ［5］ Bao B, Wang Z, Ali S, et al. Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells［J］. J Cell Biochem, 2011, 112(9): 2296-2306. DOI: 10.1002/jcb.23150. ［6］ Cui J, Xia T, Xie D, et al. HGF/c-Met and FOXM1 form a positive feedback loop and render pancreatic cancer cells resistance to Met inhibition and aggressive phenotypes［J］. Oncogene, 2016, 35(36): 4708-4718. DOI: 10.1038/onc.2016.14. ［7］ Yu H, Lee H, Herrmann A, et al. Revisiting STAT3 signalling in cancer: new and unexpected biological functions［J］. Nat Rev Cancer, 2014, 14(11): 736-746. DOI: 10.1038/nrc3818. ［8］ Patel MB, Pothula SP, Xu Z, et al. The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: antiangiogenic implications in pancreatic cancer［J］. Carcinogenesis, 2014, 35(8): 1891-1900. DOI: 10.1093/carcin/bgu122. ［9］ Gherardi E, Birchmeier W, Birchmeier C, et al. Targeting Met in cancer: rationale and progress［J］. Nat Rev Cancer, 2012, 12(2): 89-103. DOI: 10.1038/nrc3205. ［10］ Garajova I, Giovannetti E, Biasco G, et al. c-Met as a target for personalized therapy［J］. Transl Oncogenomics, 2015, 7(Suppl 1): 13-31. DOI: 10.4137/TOG.S30534. ［11］ Chen HM, Tsai CH, Hung WC. Foretinib inhibits angiogenesis, lymphangiogenesis and tumor growth of pancreatic cancer in vivo by decreasing VEGFR-2/3 and TIE-2 signaling［J］. Oncotarget, 2015, 6(17): 14940-14952. DOI: 10.18632/oncotarget.3613. ［12］ Grullich C. Cabozantinib: a Met, RET, and VEGFR2 tyrosine kinase inhibitor［J］. Recent Results Cancer Res, 2014, 201: 207-214. DOI: 10.1007/978-3-642-54490-3_12. ［13］ Hage C, Rausch V, Giese N, et al. The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer［J］. Cell Death Dis, 2013, 4(5): e627-e627. DOI: 10.1038/cddis.2013.158. ［14］ Zhen DB, Griffith KA, Ruch JM, et al. A phase Ⅰ trial of cabozantinib and gemcitabine in advanced pancreatic cancer［J］. Invest New Drugs, 2016, 34(6): 733-739. DOI: 10.1007/s10637-016-0376-1. ［15］ You WK, Sennino B, Williamson CW, et al. VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer［J］. Cancer Res, 2011, 71(14): 4758-4768. DOI: 10.1158/0008-5472.CAN-10-2527. ［16］ Liu XD, Wang Q, Yang GJ, et al. A novel kinase inhibitor, INCB28060, blocks c-MET-Dependent signaling, neoplastic activities, and Cross-Talk with EGFR and HER3［J］. Clin Cancer Res, 2011, 17(22): 7127-7138. DOI: 10.1158/1078-0432.CCR-11-1157. ［17］ Brandes F, Schmidt K, Wagner C, et al. Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model［J］. BMC Cancer, 2015, 15: 71. DOI: 10.1186/s12885-015-1064-9.

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Research progress of HGF/c-MET signaling pathway inhibitors in antipancreatic cancer

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