m<sup>6</sup>A methylation and breast cancer

Abstract

Abstract:

m⁶A methylation can regulate RNA metabolism and participates in the pathogenesis of breast cancer. m⁶A methyltransferase, demethylase and methylated binding protein regulate the dynamic and reversible process of m⁶A methylation modification together. In recent years, studies have shown that methyltransferase-like (METTL)3, MELLT14, KIAA1429, fat-mass and obesity associated protein, YTH domain family member 1-3 and other related factors are abnormally expressed in breast cancer, which may affect the occurrence and development of breast cancer by regulating the methylation and demethylation process of m⁶A. Further studies will provide a new idea and target for clinical diagnosis and treatment of breast cancer.

Key words:Methylation,Breast neoplasms,Regulatory proteins

Yin Jianyun, Wang Peiwei, Gu Jianwei. m⁶A methylation and breast cancer[J]. Journal of International Oncology, 2020, 47(12): 752-755.

References31

[1]	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017[J]. CA Cancer J Clin, 2017,67(1):7-30. DOI: 10.3322/caac.21387. doi:10.3322/caac.21387pmid:28055103
[2]	Miller KD, Siegel RL, Lin CC, et al. Cancer treatment and survivorship statistics, 2016[J]. CA Cancer J Clin, 2016,66(4):271-289. DOI: 10.3322/caac.21349. doi:10.3322/caac.21349pmid:27253694
[3]	Lan Q, Liu PY, Haase J, et al. The critical role of RNA m⁶A methylation in cancer[J]. Cancer Res, 2019,79(7):1285-1292. DOI: 10.1158/0008-5472.CAN-18-2965. doi:10.1158/0008-5472.CAN-18-2965pmid:30894375
[4]	Liu Q, Gregory RI. RNAmod: an integrated system for the annotation of mRNA modifications[J]. Nucleic Acids Res, 2019,47(W1):W548-W555. DOI: 10.1093/nar/gkz479. doi:10.1093/nar/gkz479pmid:31147718
[5]	Liu N, Zhou KI, Parisien M, et al. N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein[J]. Nucleic Acids Res, 2017,45(10):6051-6063. DOI: 10.1093/nar/gkx141. doi:10.1093/nar/gkx141pmid:28334903
[6]	Pan Y, Ma P, Liu Y, et al. Multiple functions of m⁶A RNA methylation in cancer[J]. J Hematol Oncol, 2018,11(1):48. DOI: 10.1186/s13045-018-0590-8. doi:10.1186/s13045-018-0590-8pmid:29587823
[7]	Roundtree IA, Evans ME, Pan T, et al. Dynamic RNA modifications in gene expression regulation[J]. Cell, 2017,169(7):1187-1200. DOI: 10.1016/j.cell.2017.05.045. doi:10.1016/j.cell.2017.05.045pmid:28622506
[8]	Wang H, Xu B, Shi J. N⁶-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2[J]. Gene, 2020,722:144076. DOI: 10.1016/j.gene.2019.144076. doi:10.1016/j.gene.2019.144076pmid:31454538
[9]	Cai X, Wang X, Cao C, et al. HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g[J]. Cancer Lett, 2018,415:11-19. DOI: 10.1016/j.canlet.2017.11.018. doi:10.1016/j.canlet.2017.11.018pmid:29174803
[10]	Wang P, Doxtader KA, Nam Y. Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases[J]. Mol Cell, 2016,63(2):306-317. DOI: 10.1016/j.molcel.2016.05.041. doi:10.1016/j.molcel.2016.05.041pmid:27373337
[11]	Yi D, Wang R, Shi X, et al. METTL14 promotes the migration and invasion of breast cancer cells by modulating N6 methyladenosine and hsa miR 146a 5p expression[J]. Oncol Rep, 2020,43(5):1375-1386. DOI: 10.3892/or.2020.7515. doi:10.3892/or.2020.7515pmid:32323801
[12]	Wu L, Wu D, Ning J, et al. Changes of N⁶-methyladenosine modulators promote breast cancer progression[J]. BMC Cancer, 2019,19(1):326. DOI: 10.1186/s12885-019-5538-z. doi:10.1186/s12885-019-5538-zpmid:30953473
[13]	Yue Y, Liu J, Cui X, et al. VIRMA mediates preferential m⁶A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation[J]. Cell Discov, 2018,4:10. DOI: 10.1038/s41421-018-0019-0. doi:10.1038/s41421-018-0019-0pmid:29507755
[14]	Qian JY, Gao J, Sun X, et al. KIAA1429 acts as an oncogenic factor in breast cancer by regulating CDK1 in an N6-methyladenosine-independent manner[J]. Oncogene, 2019,38(33):6123-6141. DOI: 10.1038/s41388-019-0861-z. doi:10.1038/s41388-019-0861-zpmid:31285549
[15]	Deng X, Su R, Feng X, et al. Role of N⁶-methyladenosine modification in cancer[J]. Curr Opin Genet Dev, 2018,48:1-7. DOI: 10.1016/j.gde.2017.10.005. doi:10.1016/j.gde.2017.10.005pmid:29040886
[16]	Niu Y, Lin Z, Wan A, et al. RNA N⁶-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3[J]. Mol Cancer, 2019,18(1):46. DOI: 10.1186/s12943-019-1004-4. doi:10.1186/s12943-019-1004-4pmid:30922314
[17]	Xu Y, Ye S, Zhang N, et al. The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer[J]. Cancer Commun (Lond), 2020,40(10):484-500. DOI: 10.1002/cac2.12075.
[18]	Zhang C, Samanta D, Lu H, et al. Hypoxia induces the breast can-cer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA[J]. Proc Natl Acad Sci U S A, 2016,113(14):E2047-2056. DOI: 10.1073/pnas.1602883113. doi:10.1073/pnas.1602883113pmid:27001847
[19]	Zhang C, Zhi WI, Lu H, et al. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells[J]. Oncotarget, 2016,7(40):64527-64542. DOI: 10.18632/oncotarget.11743. doi:10.18632/oncotarget.11743pmid:27590511
[20]	Meyer KD, Jaffrey SR. Rethinking m⁶A readers, writers, and erasers[J]. Annu Rev Cell Dev Biol, 2017: 33:319-342. DOI: 10.1146/annurev-cellbio-100616-060758. doi:10.1146/annurev-cellbio-100616-060758pmid:28759256
[21]	Patil DP, Pickering BF, Jaffrey SR. Reading m⁶A in the transcriptome: m6A-binding proteins[J]. Trends Cell Biol, 2018,28(2):113-127. DOI: 10.1016/j.tcb.2017.10.001. doi:10.1016/j.tcb.2017.10.001pmid:29103884
[22]	Wang X, Zhao BS, Roundtree IA, et al. N(6)-methyladenosine modulates messenger RNA translation efficiency[J]. Cell, 2015,161(6):1388-1399. DOI: 10.1016/j.cell.2015.05.014. doi:10.1016/j.cell.2015.05.014pmid:26046440
[23]	Shi H, Wang X, Lu Z, et al. YTHDF3 facilitates translation and decay of N⁶-methyladenosine-modified RNA[J]. Cell Res, 2017,27(3):315-328. DOI: 10.1038/cr.2017.15. doi:10.1038/cr.2017.15pmid:28106072
[24]	Xiao W, Adhikari S, Dahal U, et al. Nuclear m⁶A reader YTHDC1 regulates mRNA splicing[J]. Mol Cell, 2016, 61(4): 507-519. DIO: 10.1016/j.molcel. 2016. 01. 012.
[25]	Hsu PJ, Zhu Y, Ma H, et al. Ythdc2 is an N⁶-methyladenosine binding protein that regulates mammalian spermatogenesis[J]. Cell Res, 2017,27(9):1115-1127. DOI: 10.1038/cr.2017.99. doi:10.1038/cr.2017.99pmid:28809393
[26]	Meyer KD, Patil DP, Zhou J, et al. 5'UTR m⁶A promotes cap-independent translation[J]. Cell, 2015,163(4):999-1010. DOI: 10.1016/j.cell.2015.10.012. doi:10.1016/j.cell.2015.10.012pmid:26593424
[27]	Liu L, Liu X, Dong Z, et al. N6-methyladenosine-related genomic targets are altered in breast cancer tissue and associated with poor survival[J]. J Cancer, 2019,10(22):5447-5459. DOI: 10.7150/jca.35053. doi:10.7150/jca.35053pmid:31632489
[28]	Alarcón CR, Goodarzi H, Lee H, et al. HNRNPA2B1 is a mediator of m⁶A-dependent nuclear RNA processing events[J]. Cell, 2015,162(6):1299-1308. DOI: 10.1016/j.cell.2015.08.011. doi:10.1016/j.cell.2015.08.011pmid:26321680
[29]	Liu N, Dai Q, Zheng G, et al. N⁶-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions[J]. Nature, 2015,518(7540):560-564. DOI: 10.1038/nature14234. doi:10.1038/nature14234pmid:25719671
[30]	Liu N, Zhou KI, Parisien M, et al. N⁶-methyladenosine alters RNA structure to regulate binding of a low-complexity protein[J]. Nucleic Acids Res, 2017,45(10):6051-6063. DOI: 10.1093/nar/gkx141. doi:10.1093/nar/gkx141pmid:28334903
[31]	Klinge CM, Piell KM, Tooley CS. HNRNPA2/B1 is upregulated in endocrine-resistant LCC9 breast cancer cells and alters the miRNA transcriptome when overexpressed in MCF-7 cells[J]. Sci Rep, 2019,9(1):9430. DOI: 10.1038/s41598-019-45636-8. doi:10.1038/s41598-019-45636-8pmid:31263129

m⁶A methylation and breast cancer

RichHTML

PDF

Knowledge

Abstract

Cite this article

share this article

References31

Related Articles15

Recommended Articles

Metrics

Comments

[1]	Wang Ying, Liu Nan, Guo Bing.Advances of antibody-drug conjugate in the therapy of metastatic breast cancer[J]. Journal of International Oncology, 2024, 51(6): 364-369.
[2]	Sa Qiang, Xu Hangcheng, Wang Jiayu.Advances in immunotherapy for breast cancer[J]. Journal of International Oncology, 2024, 51(4): 227-234.
[3]	Yang Zhi, Lu Yiqiao, Gu Huayan, Ding Jialing, Guo Guilong.Research progress of tumor microenvironment mediated drug resistance in targeted therapy of breast cancer[J]. Journal of International Oncology, 2024, 51(4): 235-238.
[4]	Chen Boguang, Wang Sugui, Zhang Yongjie.Role of serum cholinesterase and inflammatory markers in the prognosis of stage ⅠA -ⅢA breast cancer[J]. Journal of International Oncology, 2024, 51(2): 73-82.
[5]	Gu Huayan, Zhu Teng, Guo Guilong.Breast microbiota and breast cancer： present and future[J]. Journal of International Oncology, 2024, 51(1): 55-58.
[6]	Wang Jing, Xu Wenting.Value of NLR， CEA combined with coagulation indicators in the differential diagnosis of benign and malignant breast nodules with a diameter ≤ 1.0 cm[J]. Journal of International Oncology, 2023, 50(9): 520-526.
[7]	Feng Chengtian, Huang Furong, Cao Shiyu, Wang Jianyu, Nanding Abiyasi, Jiang Yongdong, Zhu Juanying.Relationships between HER2 protein expression and imaging features in HER2 positive breast cancer patients[J]. Journal of International Oncology, 2023, 50(9): 527-531.
[8]	Feng Dongxu, Wu Wei, Gao Pingfa, Wang Jun, Shi Lijuan, Chen Dawei, Li Wenbing, Zhang Meifeng.Effects of miR-451 on glycolysis and apoptosis of breast cancer cells by regulating Rho/ROCK1 pathway[J]. Journal of International Oncology, 2023, 50(8): 449-456.
[9]	Pan Shulan, Liu Chang, He Ping.Effect of fritinib on angiogenesis, tumor growth and IRE1-ASK1-JNK pathway in triple negative breast cancer[J]. Journal of International Oncology, 2023, 50(8): 457-462.
[10]	Wang Wende, Zeng De.Research progress on the mechanism of endocrine therapy resistance for breast cancer[J]. Journal of International Oncology, 2023, 50(6): 352-356.
[11]	Li Qingshan, Xie Xin, Zhang Nan, Liu Shuai.Research progress on the application of combining radiotherapy and systemic therapy in breast cancer[J]. Journal of International Oncology, 2023, 50(6): 362-367.
[12]	Zhu Jun, Huang Meijin, Li Yuan, Liu Zegang, Xun Xin, Chen Hong.Research progress on targeted therapy of breast cancer with low expression of HER2[J]. Journal of International Oncology, 2023, 50(4): 236-240.
[13]	Zhou Ting, Xu Shaohua, Mei Lin.Efficacy and safety of bevacizumab combined with capecitabine in the treatment of advanced breast cancer[J]. Journal of International Oncology, 2023, 50(3): 144-149.
[14]	Li Lixi, Zhang Di, Luo Yang, Ma Fei.Clinical application of PARP inhibitors in breast cancer[J]. Journal of International Oncology, 2023, 50(2): 91-96.
[15]	Geng Rui, Ma Junqiang, Guo Qiang, Niu Zhaofeng.Tendency of elderly patients with breast cancer to choose comprehensive treatment mode and its influencing factors[J]. Journal of International Oncology, 2023, 50(11): 650-654.

m6A methylation and breast cancer

RichHTML

PDF

Knowledge

Abstract

Cite this article

share this article

References31

Related Articles15

Recommended Articles

Metrics

Comments

m⁶A methylation and breast cancer