Abstract:MicroRNA is a class of non-protein coding, single-stranded small RNAs of 22-25 nucleotides length. It takes part in many physiological processes including tumorigenesis. In the present focus studis, molecular biology and bioinformatics methods are used to study the role of miRNA in endometrial carcinoma. Several miRNAs with research value have been found and their mechanisms have been investigated. Results from the studis provid valid evidence for further research.