Abstract:High-altitude hypoxia is closely associated with cancer initiation and progression. Hypoxia promotes tumor development through multiple mechanisms including modifying acidic microenvironment, triggering tumor angiogenesis, influencing vasculogenic mimicry, inducing epithelial-mesenchymal transition, remodeling of extracellular matrix, promoting immune escape and adaptive landscapes, maintaining cancer stem cells and inhibiting senescence. Targeting hypoxia may become a novel efficient strategy for cancer therapy.

Key words:font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt">Neoplasmsfont-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体,mso-font-kerning: 1.0pt,mso-bidi-font-size: 10.5pt">,font-family: "Times New Roman",mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA,mso-fareast-font-family: 宋体">Anoxia