Abstract:Angiogenesis and invasion are two remarkable features of spongioblastoma, which lead to the failure of clinical treatment. With the development of the glioma’s molecular biology mechanism in the realm of angiogenesis, some anti-angiogenesisdrugs have got a positive therapeutic efficacy in the clinical trials, such as bevacizumab. However, it is reported that these drugs maybe also enhance the invasion and migration ability of glioma cells in the process of anti-angiogenesis therapy. Matrix metalloproteinases, hypoxia induced factor-1 and the inositol-requiring enzyme-1 maybe have some correlations with the change of the invasion and migration, but the molecular biological mechanism needs further research.

Key words:Glioblastoma,Invasion,Anoxi,Bevacizumab