Abstract:Recent studies suggest that astrocyte elevated gene 1 (AEG-1) is almost highly expressed in all types of malignant solid tumors and correlates with poor prognosis, which becomes a prognostic marker for many kinds of tumors. As a strongly basic protein, AEG-1 possesses a transmembrane domain and multiple nuclear localization signals. It is present in the cell membrane, cytoplasm and nucleus. As an oncogene, AEG-1 palys an important role in a virety of malignant biological behaviors of cancer, which range from cell proliferation, apoptosis, migration, adhesion, invasion to tumor angiogenesis and chemotherapy resistance. Its critical role in tumor genesis and progression has made it a potential therapeutic target.

Key words:Neoplasms,Oncogenes