Abstract:Tumor angiogenesis is an important way of rapid proliferation and metastasis for malignancies, and a variety of cellular and molecular factors involved in the process. Angiopoietin-2（Ang-2） is one of the important vascular endothelial growth factor, which influences tumor angiogenesis mainly through releasing vascular structures and damaging the vessel stability. Recent researches reveal that Ang-2 modulates tumor angiogenesis interacting with other vascular growth factors. With the new research progress, Ang-2 will not only be an important target for antiangiogenic therapy, but also further improve clinical efficacy of antitumor therapy combined with other signal pathways as common targets.

Key words:Angiopoietins,Neoplasms,Neovascularization, pathologic