Journal of International Oncology

Journal of International Oncology››2012,Vol. 39››Issue (7): 489-492.

Previous ArticlesNext Articles

Pregnane X receptor and tumor multidrug resistance

QIAO En-qi, TANG Jin-Hai, WU Jian-Zhong

  1. Department of General Surgery, Jiangsu Cancer Hospital, Affiliated to Nanjing Medical University, Nanjing 210009, China
  • Online:2012-08-06Published:2012-08-06
  • Contact:TANG Jin-hai, E-mail: qiaoenqi66@sina.com E-mail:qiaoenqi66@sina.com

PDF

1734

Abstract:The overexpression of P-glycoprotein (P-gp) and its coding gene mdr1 is regarded as the classic mechanism of multidrug resistance (MDR). Recent studies find that pregnane X receptor (PXR) can mediate the expression of P-gp. It is confirmed that PXR can also inhibit apoptosis of tumor cells. Therefore, preventing the activation of PXR specifically may be a new method to prevent MDR.

Key words:Drug resistance, neoplasm,P-glycoprotein,Pregnane X receptor