Abstract:Microglia (MG) is recognized as the main immune effector in central nervous system injury and disease. MG can regulate the tumorigenesis and development of brain metastases tumor (BMT) by different ways. Studing the roles and mechanisms of MG in BMT will provide new insights into the prevention and treatment of BMT.

Key words:Microglia,Brain neoplasms,Nitric oxide,Tumor necrosis factor-alpha,Endothelin-1