Abstract:Aberrations of the mammalian target of rapamycin (mTOR) signaling are frequently observed in many types of cancer. Activation of mTOR regulates tumor cell proliferation, survival and metastasis,and then results tumorigenesis and tumor developmet,Blocking the mTOR signaling pathway by rapamycin and its derivatives can inhibit gastric cancer cell growth and promote tumor necrosis and such effects can be synergistically improved by combined use of other chemotherapeutic agents．Thus，rapamyein and its derivatives may be effective in the prevention and treatment of gastric cancer．

Key words:color: black,font-size: 12pt,mso-bidi-font-family: 'Times New Roman',mso-font-kerning: 1.0pt,mso-ansi-language: EN-US,mso-fareast-language: ZH-CN,mso-bidi-language: AR-SA" lang="EN-US">Stomach neoplasms,Sirolimus,Mammalian target of rapamycin