Abstract:Histone deacetylase7(HDAC7) belongs to Ⅱa histone deacetylases. HDAC7 can alter chromosome structure and regulate gene transcription, and plays an important role in tumorigenesis and tumor angiogenesis. Increasing evidences show that HDAC7 can maintain the vascular integrity and continuity, and regulate the expression of angiogenic genes. HDAC7 also can regulate the migration and proliferation of vascular endothelial cells, and regulate angiogenic effect mediated by VEGF and other proangiogenenic factors contributing to tumor angiogenesis. Therefore, studies of the mechanisms in which HDAC7 contributes to tumor angiogenesis and the development of HDAC7 inhibitors could provide a new direction to tumor diagnosis and therapy.

Key words:Histone deacetylases,Vascular endothelial growth factors,Neovascularization, pathologic