Journal of International Oncology››2013,Vol. 40››Issue (3): 184-186.

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Bmi-1 gene and radiation resistance

XIONG Bei-Bei, FAN Hua, LI Tao

  1. Department of Oncology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China
  • Online:2013-03-08Published:2013-02-25
  • Contact:LI Tao, E-mail: litaoxmf@126.com E-mail:litaoxmf@126.com

Abstract:As a transcriptional repressor, Bmi-1 is a member of polyeomb group gene family. It may play an important role in self-renewal ability and proliferation of stem cell. At present, studies show that Bmi-1is highly expressedin a variety of solid tumors, which can be regarded as one of the markers of cancer stem cells and has a close relation to the cancer development and progression and radiation resistance. It will provide an important target gene for the treatment of malignant tumors.

Key words:Neoplastic stem cells,Radiotherapy,Bmi-1 gene