Journal of International Oncology››2013,Vol. 40››Issue (10): 732-735.

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Research about NNMT gene in cancer

ZHOU Wei-Min, ZHONG Kuang-biao, GUI Ming

  1. Department of Urology, Third Xiangya Hospital , Central South University , Changsha 410013, China

  • Online:2013-10-08Published:2013-09-23
  • Contact:ZHONG Kuang-biao E-mail:zkbgm@126.com

Abstract:Nicotinamide N-methyltransferase (NNMT) is a S-adenosyl-L-methionine (SAM) dependent cytoplasm enzyme, which plays a vital rolein the biotransformation and detoxification of many drugs and xenobiotic compounds. Recent studies have revealed abnormal expression of NNMT in many tumors, which may contribute to tumorigenesis andtumor developmentand radiotherapy or chemotherapy resistance.

Key words:Nicotinamide N-methyltransferase,Nicotinamide,Neoplasms