Basis of molecular pathology in colorectal carcinogenesis

Abstract

Jiang Weiguo, Huang Youguang. Basis of molecular pathology in colorectal carcinogenesis[J]. Journal of International Oncology, 2014, 41(5): 353-357.

［1］李祯, 生秀杰. 结肠癌转移相关基因1与肿瘤［J］. 国际肿瘤学杂志, 2013, 40(1):15-18. ［2］ Gavin PG, Colangelo LH, Fumagalli D, et al. Mutation profiling and microsatellite instability in stage Ⅱ and Ⅲ colon cancer: an assessment of their prognostic and oxaliplatin predictive value［J］. Clin Cancer Res, 2012, 18(23):6531-6541. ［3］ Lagarde P, Pérot G, Kauffmann A, et al. Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors［J］. Clin Cancer Res, 2012, 18(3):826-838. ［4］ Shull AY, Clendenning ML, GhoshalGupta S, et al. Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients［J］. PLoS One, 2013, 8(3):e58731. ［5］ Pagin A, Zerimech F, Leclerc J, et al. Evaluation of a new panel of six mononucleotide repeat markers for the detection of DNA mismatch repairdeficient tumours［J］. Br J Cancer, 2013, 108(10):2079-2087. ［6］ Sinicrope FA, Sargent DJ. Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications［J］. Clin Cancer Res, 2012, 18(6):1506-1512. ［7］ Pinheiro M, Ahlquist T, Danielsen SA, et al. Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin［J］. BMC Cancer, 2010, 10:587-596. ［8］ Chen W, Yuan L, Cai Y, et al. Identification of chromosomal copy number variations and novel candidate loci in hereditary nonpolyposis colorectal cancer with mismatch repair proficiency［J］. Genomics, 2013, 102(1):27-34. ［9］ Fournier A, Sasai N, Nakao M, et al. The role of methylbinding proteins in chromatin organization and epigenome maintenance［J］. Brief Funct Genomics, 2012, 11(3):251-264. ［10］ Walton EL, Francastel C, Velasco G. Maintenance of DNA methylation: Dnmt3b joins the dance［J］. Epigenetics, 2011, 6(11):1373-1377. ［11］ Bae JM, Kim JH, Cho NY, et al. Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location［J］. Br J Cancer, 2013, 109(4):1004-1012. ［12］ Bae JM, Kim JH, Kang GH. Epigenetic alterations in colorectal cancer: the CpG island methylator phenotype［J］. Histol Histopathol, 2013, 28(5):585-595. ［13］ Markowitz SD, Bertagnolli MM. Molecular origins of cancer: Molecular basis of colorectal cancer［J］. N Engl J Med, 2009, 361(25):2449-2460. ［14］ Gay LJ, Mitrou PN, Keen J, et al. Dietary, lifestyle and clinicopathological factors associated with APC mutations and promoter methylation in colorectal cancers from the EPICNorfolk study［J］. J Pathol, 2012, 228(3):405-415. ［15］ Zhang T, Fields JZ, Opdenaker L, et al. Survivininduced AuroraB kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development［J］. Am J Pathol, 2010, 177(6):2816-2826. ［16］ Lau T, Chan E, Callow M, et al. A novel tankyrase smallmolecule inhibitor suppresses APC mutationdriven colorectal tumor growth［J］. Cancer Res, 2013, 73(10):3132-3144. ［17］侯庆生, 丁渭, 陈德喜. p53凋亡刺激蛋白2对饥饿诱导的大肠癌HCT116p53+/+细胞凋亡、周期和自噬的影响［J］. 国际肿瘤学杂志, 2013, 40(4):298-302. ［18］ Yang W, Rozan LM, McDonald ER, et al. CARPs are ubiquitin ligases that promote MDM2independent p53 and phosphop53ser20 degradation［J］. J Biol Chem, 2007, 282(5):3273-3281. ［19］ Muller PA, Vousden KH. p53 mutations in cancer［J］. Nat Cell Biol, 2013, 15(1):2-8. ［20］ Pineda M, González S, Lázaro C, et al. Detection of genetic alterations in hereditary colorectal cancer screening［J］. Mutat Res, 2010, 693(1-2):19-31. ［21］ Bellam N, Pasche B. Tgfbeta signaling alterations and colon cancer［J］. Cancer Treat Res, 2010, 155:85-103. ［22］ Lee J, Ballikaya S, Schnig K, et al. Transforming growth factor beta receptor 2 (TGFBR2) changes sialylation in the microsatellite unstable (MSI) Colorectal cancer cell line HCT116［J］. PLoS One, 2013, 8(2):e57074. ［23］ Shima K, Morikawa T, Yamauchi M, et al. TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers［J］. PLoS One, 2011, 6(9):e25062. ［24］ Fleming NI, Jorissen RN, Mouradov D, et al. Eppert K, SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer［J］. Cancer Res, 2013, 73(2):725-735. ［25］ Stankic M, Pavlovic S, Chin Y, et al. TGFβId1 signaling opposes twist1 and promotes metastatic colonization via a mesenchymaltoepithelial transition［J］. Cell Rep, 2013, 5(5):12281242. ［26］ Berlin J. Beyond exon 2—the developing story of RAS mutations in colorectal cancer［J］. N Engl J Med, 2013, 369(11):1059-1060. ［27］ Ogino S, Liao X, Imamura Y, et al. Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial［J］. J Natl Cancer Inst, 2013, 105(23):1789-1798. ［28］ Mao M, Tian F, Mariadason JM, et al. Resistance to BRAF inhibition in BRAFmutant colon cancer can be overcome with PI3K inhibition or demethylating agents［J］. Clin Cancer Res, 2013, 19(3):657-667. PMID: 23251002 ［29］ Slomovitz BM, Coleman RL. The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer［J］. Clin Cancer Res, 2012, 18(21):5856-5864.

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Basis of molecular pathology in colorectal carcinogenesis

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