Journal of International Oncology››2015,Vol. 42››Issue (1): 43-45.doi:10.3760/cma.j.issn.1673-422X.2015.01.011

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Transforming growth factor-β and tumor

Tang Nailing, Guo Zhi, Yang Xueling

  1. Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center of Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China
  • Received:2014-06-18Revised:2014-08-04Online:2015-01-08Published:2015-01-07
  • Contact:Guo Zhi E-mail:cjr.guozhi.@vip.163.com

Abstract:Many studies show that transforming growth factorβ (TGFβ) can suppress tumor by inhibiting proliferation and dedifferentiation of cells and promoting cell apoptosis at early stage. But during the progression of tumor, its tumorpromoting action will be more and more obvious with the variation of TGFβ itself and its signal path. TGFβ signal path inhibitors have antitumor activity, but the clinical effects and side effects still need to be observed.

Key words:Transforming growth factor β,Neoplasms,Inhibitors