Abstract:Combined small cell lung cancer (CSCLC) is a special subtype of small cell lung cancer (SCLC), which has a low incidence and diagnostic rate. However, the incidence and diagnostic rate appear an increasing tendency recently. The clinical features of CSCLC are similar to the pure SCLC, while it has a relatively limited stage. The main treatment pattern of CSCLC is multimodality therapy, though the response to chemotherapy in CSCLC is relatively poor. Survival between patients with CSCLC versus SCLC is similar. KPS, stage, composite components, tumor location and diameter, surgery margin are prognostic factors. Radiotherapy can benefit for the patients with ⅢA/ⅢB disease, positive lymph nodes, or with more metastatic lymph nodes after surgery.

Key words:Diagnosis,Therapy,Prognosis,Lung neoplasms