Journal of International Oncology››2015,Vol. 42››Issue (7): 516-518.doi:10.3760/cma.j.issn.1673-422X.2015.07.010

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Inducible costimulatory molecule and its roles in tumor microenvironment

Wu Dongjuan, Hua Dong

  1. Department of Oncology, Fourth Affiliated Hospital of Soochow University & Wuxi Fourth People′s Hospital, Wuxi 214062, China
  • Online:2015-07-08Published:2015-05-26
  • Contact:Hua Dong E-mail:wx89211@163.com

Abstract:Inducible costimulatory molecule (ICOS) is a member of the CD28 family, which can be expressed on the tumor tissues and immune cells in the tumor microenvironment. ICOS enhances its antitumor activity through participating in CD4+ T and CD8+ T cell immune response and enhancing the secretion of cytokines on the activated T cells and NK cells. While the curative effect of cytotoxic T lymphocyteassociated antigen4 (CTLA4) monoclonal antibody is relevant with CD4+ T cells expressing ICOS, which suggesting ICOS may become a novel antitumor therapeutic target in the future.

Key words:Immunity,Tumor microenvironment,Inducible costimulatory molecule