Journal of International Oncology››2015,Vol. 42››Issue (10): 750-752.doi:10.3760/cma.j.issn.1673-422X.2015.10.008

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Mechanism of Raf kinase inhibitor protein down-regulation in cancer

Wang Yun, Li Yuhong

  1. Department of Medical Oncology, Sun YatSen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
  • Online:2015-10-08Published:2015-09-08
  • Contact:Li Yuhong E-mail:liyh@sysucc.org.cn

Abstract:Raf -kinase inhibiting protein (RKIP) plays a vital role in various physiological processes and participates in multiple signaling pathways, with a close releationgship with tumor. The mechanism of RKIP down-regulation in neoplasms includes transcriptional regulation, methylation, acetylation, histone modification, microRNA regulation and NF-κB/Snail/RKIP loop regulation.

Key words:Phosphatidylethanolamine binding protein,Neoplasms,Gene expression regulation