Journal of International Oncology››2016,Vol. 43››Issue (2): 110-.

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Role and regulatory mechanism of microRNA449 in cancer

WANG Xiao-Li, CHANG Yong-Chao, LIU Gang

  1. Clinical Laboratory, First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, China
  • Online:2016-02-08Published:2015-12-28

Abstract:More than 50% microRNAs (miRNAs) are located in tumorassociated genome of amplification region or fragile site, which may also act as oncogenes or tumor suppressor gene (TSG). Recently, researches show that the expression of miR449 is lower in human gastric, lung and ovarian cancer, and may act as TSG. The abnormal expression of miR449 plays a pivotal role in carcinogenesis and progression, and elucidating its function and regulatory mechanism can provide valuable diagnostic, prognostic biomarker for cancer management.

Key words:Neoplasms,Gene regulatory networks,microRNA-449