Journal of International Oncology

Journal of International Oncology››2016,Vol. 43››Issue (4): 262-266.doi:10.3760/cma.j.issn.1673422X.2016.04.006

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Analysis of prognostic factors and different treatment modalities for patients with early cervical squamous cell carcinoma after surgery in Xinjiang

Zhang Lei, Sun Ruirui, Zhao Huarong, Huerxidan·Niyazi, Zhang Song′an, Reheman·Yiming, Zhang Yafei, Wang Shanshan

  1. Oncology Center of First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China
  • Online:2016-04-08Published:2016-03-02
  • Contact:Zhao Huarong E-mail:xydyfyzhr@163.com
  • Supported by:

    Natural Science Foundation of First Affiliated Hospital of Xinjiang Medical University (2015ZRQN29); Urumqi Key Laboratory of Cancer and Infection (Training Base) Open Topic (WIT201301)

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Abstract:ObjectiveTo explore prognostic factors and different treatment modalities efficacy for patients with early cervical squamous cell carcinoma postoperative. MethodsThe clinical pathologic parameters in 130 inpatients of cervical squamous cell carcinoma after surgical were retrospectively analyzed. The patients were followed up for 5 years. The survival rate was calculated by KaplanMeier method and the difference was compared by Logrank test. Multivariate analysis was performed using Cox regression model. ResultsUnivariate analysis showed that parity（χ2=7.378, P=0.007), Federation International of Gynecology and Obstetrics (FIGO) stage (χ2=4.124, P=0.042), tumor size (χ2=4.070, P=0.044), lymph node metastasis (χ2=11.936, P=0.001), treatment approach (χ2=8.523, P=0.014), serum level of squamous cell carcinoma antigen (SCCA) (χ2=6.399, P=0.011）and platelet and lymphocyte ratio (PLR) (χ2=5.588, P=0.018) impact on the 5year survival rate. Multivariate analysis showed that parity (OR=4.379, 95%CI: 1.49212.854, χ2=7.226, P=0.007), FIGO stage (OR=4.129, 95%CI: 1.40112.168, χ2=7.827, P=0.005), lymph node metastasis (OR=7.312, 95%CI: 2.61720.430, χ2=14.819, P=0.000), treatment approach (OR=0.242, 95%CI: 0.0820.713, χ2=6.662, P=0.010) and PLR (OR=5.375, 95%CI: 1.35121.375, χ2=5.862, P=0.017) were independent prognostic factors for cervical squamous cell carcinoma patients. In 106 cases of patients with risk factors of cervical squamous cell carcinoma, patients who having surgery alone, surgery plus radiotherapy, surgery plus chemoradiotherapy had 5year survival rates of 61.8%, 83.3% and 90.4%, respectively, and the difference was statistical significant (χ2=8.467, P=0.014). ConclusionParity, FIGO stage, lymph node metastasis, treatment approach and PLR are independent prognostic factors in patients with early cervical squamous cell carcinoma. Adjuvant therapy is recommended in cervical cancer patients with risk factors after operation, it can improve patients′ survival rates and quality of life.

Key words:Uterine cervical neoplasms,Prognosis