Detection technologies of circulating tumor cells

Abstract

Abstract:Circulating tumor cells (CTCs) detections have unique advantages in the realtime personalized medicine of patients with tumors. The rarity and heterogeneity of CTCs in peripheral blood pose great technical challenge for CTCs researches. Most of technologies for detecting CTCs have been developed to enrich CTCs by virtue of physical properties or specific biological features of the cells at first, then genotype or phenotype analysis are performed to count or characterize CTCs. Advances in molecular analysis of single cells enable CTCs detections to provide more accurate and comprehensive information. Biological processes during CTCs invasion and metastasis such as epithelialmesenchymal transition and clustering should to be considered seriously to promote the clinical applications of CTCs detection.

Key words:Neoplasms circulating cells,Detection technology,Epithelialmesenchymal transition

Li Shuling, Liu Jing, Wei Wenqing. Detection technologies of circulating tumor cells[J]. Journal of International Oncology, 2016, 43(5): 368-371.

References

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