经鼻高流量湿化氧疗(HFNC)治疗AECOPD合并呼吸衰竭患者的临床效果及安全性

doi:10.3969/j.issn.1004-7115.2021.02.013

摘要/Abstract

摘要： 目的分析AECOPD(慢性阻塞性肺部疾病急性加重)合并呼吸衰竭患者经鼻高流量湿化氧疗(HFNC)治疗的临床效果及安全性。方法于2018年1月—2020年5月为时限,以接受治疗的AECOPD合并呼吸衰竭患者90例为对象,依据不同干预方案分设2组对照研究,各为45例。采用气囊型面罩吸氧治疗参照组,采用HFNC治疗参照组。比较两组对象血气分析变化水平、口腔舒适度、干燥度等评分、恢复情况、并发症及生存质量。结果两组对象对比治疗后SpO₂、PaCO₂、PaO₂的数据表明研究组更优,差异具有统计学意义(P<0.05)。两组对象对比口腔舒适度、干燥度评分、血气改善、住院等时间、各项生存质量评分等的数据表明,研究组更优,差异具有统计学意义(P<0.05);与参照组相比,研究组的并发症发生率相对较低,但差异无统计学意义(P＞0.05)。结论 AECOPD合并呼吸衰竭患者经HFNC治疗的效果显著,即可改善患者低氧血症,提升其口腔舒适度和生活质量,还能可减少并发症,缩短住院时间,安全可靠,值得推广研究。

关键词: 慢性阻塞性肺部疾病, 急性加重, 呼吸衰竭, 经鼻高流量湿化氧疗

Abstract: Objective:To analyze the clinical effect and safety of high nasal flow humidification oxygen therapy (HFNC) in patients with AECOPD (acute exacerbation of chronic obstructive pulmonary disease) combined with respiratory failure.Methods: From January 2018 to May 2020, 90 patients with AECOPD combined with respiratory failure were selected for a control study according to their admission number. Patients with odd numbers were included into the control group.Patients with even numbers were included in the experimental group.Airbag mask was used to treat oxygen in the control group, and HFNC was used to treat the control group.The scores of blood gas analysis, oral comfort, dryness, recovery, adverse reactions and quality of life were compared between the two groups.Results: The comparison of SpO₂, PaCO₂ and PaO₂ in the two groups after treatment showed that the experimental group was significantly superior to the control group (P<0.05), which had statistical value.However, there was no significant difference between the two before treatment (P>0.05).The comparison of oral comfort, dryness score, blood gas improvement, hospitalization time and quality of life scores in the two groups showed that the experimental group was superior to the control group (P<0.05), which had statistical value;Compared with the control group, the complication rate of the study group was relatively low, but the difference was not statistically significant (P>0.05).Conclusion: The treatment of AECOPD patients with respiratory failure by HFNC has a significant effect, which can improve the hypoxemia of patients and their oral comfort and quality of life, reduce adverse reactions, shorten the length of hospital stay, and is safe and reliable.

Key words: chronic obstructive pulmonary disease, acute exacerbation, respiratory failure, high nasal flow to humidify oxygen therapy

中图分类号:

R563

刘凤沾. 经鼻高流量湿化氧疗(HFNC)治疗AECOPD合并呼吸衰竭患者的临床效果及安全性[J]. betway必威登陆网址（betway.com ）学报, 2021, 42(2): 121-123.

LIU Feng-zhan. Clinical efficacy and safety of high nasal flow humidification oxygen therapy (HFNC) in the treatment of AECOPD patients with respiratory failure[J]. Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences, 2021, 42(2): 121-123.

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