硝苯地平联合硫酸镁对妊娠高血压患者子宫动脉血流动力学、围产结局及血液黏度的影响

doi:10.3969/j.issn.1004-7115.2021.04.010

betway必威登陆网址（betway.com ）学报 ›› 2021, Vol. 42 ›› Issue (4): 273-276.DOI: 10.3969/j.issn.1004-7115.2021.04.010

硝苯地平联合硫酸镁对妊娠高血压患者子宫动脉血流动力学、围产结局及血液黏度的影响

王婷, 刘岩

郓城县人民医院妇产二科,山东菏泽 274700

收稿日期:2020-11-03 出版日期:2021-04-25 发布日期:2021-09-01
作者简介:王婷(1977—),女,山东郓城人,主治医师,本科主要从事临床产科工作。E-mail:1923669038@qq.com。
基金资助:
菏泽市科学技术局项目。

Investigation into the effects of nifedipine combined with magnesium sulfate on uterine arterial hemodynamics perinatal outcome and blood viscosity in patients with gestational hypertension

WANG Ting, LIU Yan

The Second Department of Gynecology, Yuncheng County People's Hospital obstetrics and, Heze 274700, China

Received:2020-11-03 Online:2021-04-25 Published:2021-09-01

摘要/Abstract

摘要： 目的探讨妊娠高血压患者应用硝苯地平联合硫酸镁治疗的效果,着重观察其对患者子宫动脉血流动力学、围产结局及血液黏度的影响。方法选取2017年7月至2020年7月郓城县人民医院收治的妊娠高血压患者100例,按照随机数字表法分为单独治疗组和联合治疗组,每组50例。单独治疗组患者给予硫酸镁治疗,联合治疗组在对照组基础上加用硝苯地平,对比两组的临床治疗效果、子宫动脉血流动力学、血液黏度、围产结局。结果联合治疗组的有效率高达96.00%(48/50),显著高于单独治疗组的有效率82.00%(41/50),差异有统计学意义(χ²=5.005,P＜0.05);治疗后组间比较,联合治疗组的舒张压(DBP)、收缩压(SBP)、24h尿蛋白定量、血液黏稠度水平低于单独治疗组(P<0.05);联合治疗组的RI、PI、S/D水平显著低于单独治疗组,(P<0.05);在产妇的不良围产结局发生率方面,联合治疗组为6.00%(3/50),单独治疗组为22.00%(11/50),前者显著低于后者(P<0.05);在围生儿的不良围产结局发生率方面,联合治疗组为14.00%(7/50),单独治疗组为34.00%(17/50),前者显著低于后者(P<0.05)。结论妊娠高血压患者应用硝苯地平联合硫酸镁治疗较硫酸镁单独治疗更能有效控制血压,降低血液黏度,改善子宫动脉血流动力学、围产结局,值得临床推广。

关键词: 妊娠高血压, 硝苯地平, 硫酸镁, 血液黏度, 子宫动脉血流动力学, 围产结局

Abstract: Objective: To investigate the effect of nifedipine combined with magnesium sulfate in the treatment of pregnancy hypertension, and to observe the effect of nifedipine combined with magnesium sulfate on uterine arterial hemodynamics, perinatal outcome and blood viscosity.Methods: A total of 100 patients with gestational hypertension admitted to Yuncheng County People's Hospital from July 2017 to July 2020 were selected and divided into single treatment group and combined treatment group according to random number table method, with 50 cases in each group.The patients in the single treatment group were treated with magnesium sulfate, and the patients in the combined treatment group were treated with nifedipine on the basis of the control group.The clinical treatment effect, uterine arterial hemodynamics, blood viscosity and perinatal outcome of the two groups were compared.Results: The effective rate of combined treatment group was as high as 96.00% (48/50), which was significantly higher than that of single treatment group 82.00% (41/50), and the difference was statistically significant(χ²=5.005,P<0.05).After treatment,the DBP,SBP,24h urinary protein and blood viscosity in the combined treatment group were significantly lower than those in the single treatment group (P<0.05).The levels of RI, PI and S/D in combined treatment group were significantly lower than those in single treatment group (P<0.05).The incidence of adverse perinatal outcomes was 6.00% (3/50) in the combined treatment group and 22.00% (11/50) in the single treatment group, and the former was significantly lower than the latter (P<0.05).The incidence of adverse perinatal outcomes in perinatal infants was 14.00%(7/50) in the combined treatment group and 34.00% (17/50) in the single treatment group, and the former was significantly lower than the latter (P<0.05).Conclusion: Compared with magnesium sulfate alone, nifedipine combined with magnesium sulfate can effectively control blood pressure, reduce blood viscosity, improve uterine arterial hemodynamics and perinatal outcome in patients with gestational hypertension, which is worthy of clinical promotion.

Key words: pregnancy hypertension, nifedipine, magnesium sulfate, blood viscosity, uterine arterial hemodynamics, perinatal outcome

中图分类号:

R714

王婷, 刘岩. 硝苯地平联合硫酸镁对妊娠高血压患者子宫动脉血流动力学、围产结局及血液黏度的影响[J]. betway必威登陆网址（betway.com ）学报, 2021, 42(4): 273-276.

WANG Ting, LIU Yan. Investigation into the effects of nifedipine combined with magnesium sulfate on uterine arterial hemodynamics perinatal outcome and blood viscosity in patients with gestational hypertension[J]. Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences, 2021, 42(4): 273-276.

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硝苯地平联合硫酸镁对妊娠高血压患者子宫动脉血流动力学、围产结局及血液黏度的影响

Investigation into the effects of nifedipine combined with magnesium sulfate on uterine arterial hemodynamics perinatal outcome and blood viscosity in patients with gestational hypertension

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