六味地黄丸改善骨质疏松性疼痛及骨代谢状态的临床研究

doi:10.3969/j.issn.1004-7115.2021.04.020

betway必威登陆网址（betway.com ）学报 ›› 2021, Vol. 42 ›› Issue (4): 301-304.DOI: 10.3969/j.issn.1004-7115.2021.04.020

六味地黄丸改善骨质疏松性疼痛及骨代谢状态的临床研究

徐栋

宁阳县第一人民医院骨科,山东宁阳 271400

收稿日期:2020-11-10 出版日期:2021-04-25 发布日期:2021-09-01
作者简介:徐栋(1979—),男,山东宁阳人,主治医师,主要从事手足及显微外科工作。

Clinical study on the effect of Liuwei Dihuang Pill on the pain symptom and bone metabolism in osteoporosis

XU Dong

Dept. of Orthopaedics, First People's Hospital of Ningyang County, 271400 China

Received:2020-11-10 Online:2021-04-25 Published:2021-09-01

摘要/Abstract

摘要： 目的探讨六味地黄丸缓解更年期骨质疏松性疼痛以及改善骨质代谢的临床效果。方法选择80例女性更年期骨质疏松症患者,随机数字表法分为观察组(n=40)和对照组(n=40),对照组连续口服碳酸钙片+维生素AD治疗,治疗组在对照组治疗的基础上加服六味地黄丸,两组疗程均为3个月,观察两组患者的视觉模拟疼痛评分(VAS)、数字疼痛评分(NRS)、下腰功能评分(JOA)和Oswestry功能障碍评分(ODI)的变化,以及患者骨质代谢相关指标的差异,包括骨密度(BMD)、血钙(Ca)、血磷(P)。结果治疗前,两组患者的疼痛评分及骨代谢指标比较差异无统计学意义(P>0.05)。治疗3个月后,两组VAS、NRS、JOA、ODI评分均有降低,但是治疗组评分改善的程度明显高于对照组,差异具有统计学意义(P<0.001)。两组患者的BMD、血Ca水平均有改善,但治疗组改善程度明显高于对照组,差异具有统计学意义(P<0.001)。结论六味地黄丸能有效改善更年期骨质疏松性疼痛的临床症状,并通过改善骨质代谢来降低骨质疏松程度,具有良好的临床疗效,值得进一步研究和推广。

关键词: 更年期骨质疏松, 六味地黄丸, 疼痛, 骨代谢

Abstract: Objective: To investigate the clinical effect of Liuwei Dihuang Pill on relieving menopausal osteoporosis pain and improving bone metabolism.Methods: Eighty cases of women with menopausal osteoporosis were chosen and divided into observation group (n=40) and the control group (n=40) by random number table method, control group received continuous oral calcium carbonate + vitamin AD treatment, while the treatment group also had bolus of Liuwei Dihuang Pill on the basis of control group therapy, and the course was 3 months. Visual analog pain score(VAS), digital pain score(NRS), low back function score(JOA), Oswestry disability scale(ODI) changes and the differences of bone metabolism including mineral density(BMD), blood calcium(Ca), blood phosphorus(P) in patients of the two groups were observed.Results: Before treatment, there was no significant difference in pain score and bone metabolism between the two groups (P>0.05).After 3 months of treatment, VAS, NRS, JOA and ODI scores in both groups were reduced, but the improvement of scores in the treatment group was significantly higher than that in the control group, with statistically significant difference (P<0.001). BMD, blood Ca levels in both groups were improved, while the improvement in the treatment group was significantly higher than that in the control group, and the difference was statistically significant(P<0.001).Conclusion: Liuwei Dihuang Pill can effectively improve the clinical symptoms of menopausal osteoporosis pain, and reduce osteoporosis by improving bone metabolism, which has a good clinical effect and is worthy of further study and promotion.

Key words: menopausal osteoporosis, Liuwei Dihuang pill, pain, bone metabolism

中图分类号:

R681

徐栋. 六味地黄丸改善骨质疏松性疼痛及骨代谢状态的临床研究[J]. betway必威登陆网址（betway.com ）学报, 2021, 42(4): 301-304.

XU Dong. Clinical study on the effect of Liuwei Dihuang Pill on the pain symptom and bone metabolism in osteoporosis[J]. Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences, 2021, 42(4): 301-304.

参考文献

[1] 姜朝阳,谢兴文,徐世红,等.六味地黄丸治疗绝经后骨质疏松症的研究进展[J].中医正骨, 2020,32(4):39-43.
[2] 王玺,罗志秀.六味地黄丸联合鲑鱼降钙素对改善绝经后骨质疏松性疼痛症状的临床研究[J].中国骨质疏松杂志,2018,24(11):1485-1488.
[3] Gossiel F,Paggiosi MA,Naylor KE,et al.The effect of bisphosphosphonates on bone turnover and bone balance in postmenopausal women with osteoporosis:the T-score bone marker approach in the TRIO atudy[J].Bone,2020,131:115158.
[4] 余璟玮,欧志聪.六味地黄丸对骨质疏松骨代谢及生活质量影响[J].光明中医,2016,31(15): 2157-2159.
[5] 李杨,关雪峰.中药对骨质疏松症骨代谢影响研究进展[J].辽宁中医药大学学报,2019,21(5): 94-97.
[6] Suzuki M,Orita S,Miyagi M,et al.Vertebral compression exacerbates osteoporotic pain in an ovariectomy-induced osteoporosis rat model[J].Spine,2013,38(24):2085-2091.
[7] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊疗指南(2017)[J].中国骨质疏松杂志,2019,25(3):281- 309.
[8] 郑筱庾.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出社,2002:356-365.
[9] Wei L,Zhang H,Li X,et al.Efficacy and safety evaluation of intravenous infusion of cervus and cucumis polypeptides for treatment of avascular necrosis of the femoral head:a randomized clinical trial[J].J Tradit Chin Med,2016,36(1):39-44.
[10] Yun SJ,Suh JH,Kim HY,et al.The Prognostic Value of Enhanced-MRI and Fluoroscopic Factors for Predicting the Effects of Transforaminal Steroid Injections on Lumbosacral Radiating Pain[J].Ann Rehab Med,2016,40(6):1071.
[11] 张妍,王健英,邢蕴蕴,等.中药影响骨代谢分子机制研究进展[J].中草药,2019,50(20):5096- 5102.
[12] 金华.自拟补肾强骨汤治疗骨质疏松症的疗效及对骨代谢指标的影响[J].光明中医,2020, 35(3):339-341.
[13] 陈军,桂珣,彭细香,等.补肾强骨汤对54例骨质疏松症患者骨密度和生活质量的影响[J]. 上海医药,2017,38(1):37-40.
[14] 王伟,万雷,柴爽,等.骨质疏松症的中医病因病机和分期治疗[J].中医正骨,2018,30(2):29-30.
[15] Zhu Y,Wang YM,Jia YC,et al.Catalpol promotesthe osteogenic differentiationof bone marrow mesenchymal stem cells via the Wnt2-β-catenin pathway[J].Stem Cell Res Ther, 2019,10(1):37.
[16] 黄佳纯,林燕平,陈桐莹,等.山茱萸新苷Ⅰ对成骨细胞的增殖及成骨分化的影响[J].中国骨质疏松杂志,2020,26(1):1-5.
[17] Lee S,Choi E,Yang SM,et al.Bioactive compounds from sclerotia extract of poria cocos that control adipocyte and osteoblast differentiation[J].Bioorg Chem,2018,81:27-34.
[18] 王建武,夏旭丽.六味地黄丸中有效成分的元素特征研究[J].微量元素与健康研究,2016, 33(1):41-44.
[19] 梁博程,史晓林,许超,等.基于中药系统药理学方法研究六味地黄丸治疗骨质疏松症的药效成分、作用靶点及作用特点[J].中医正骨,209,31(4):1-7.
[20] 陶乐维,陆灏.六味地黄丸治疗骨质疏松症研究进展[J].上海中医药杂志,2017,(S1):285- 287.

六味地黄丸改善骨质疏松性疼痛及骨代谢状态的临床研究

Clinical study on the effect of Liuwei Dihuang Pill on the pain symptom and bone metabolism in osteoporosis

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 2

编辑推荐

Metrics

[1]	张晓, 闫平平, 张丽娟, 阴涛, 高强, 郑遵成. TRPV4-P38α通路在背根神经节持续受压致神经病理性疼痛中的作用[J]. betway必威登陆网址（betway.com ）学报, 2021, 42(4): 254-257.
[2]	肖云久, 肖洪玲, 张贻婷, 王倩, 陈美玲. 强化疼痛护理对急诊骨科创伤患者的Meta分析[J]. betway必威登陆网址（betway.com ）学报, 2021, 42(3): 197-202.