二甲双胍在子宫内膜癌中的基础与临床研究现状

摘要/Abstract

摘要：

子宫内膜癌是常见的妇科恶性肿瘤之一,与糖尿病等代谢综合征关系密切。近年来,流行病学调查发现降糖药物二甲双胍对于子宫内膜癌的预防和治疗有积极作用,且大量的基础研究和临床研究皆支持这一理论,预示着二甲双胍可能会成为子宫内膜癌(特别是晚期和复发性子宫内膜癌)患者及子宫内膜不典型增生患者重要的治疗手段。

关键词:子宫内膜肿瘤,二甲双胍,糖尿病,胰岛素抗药性

Abstract:

Endometrial cancer is one of the most common gynecological malignancies, which is closely related to metabolic syndrome such as diabetes mellitus. In recent years, epidemiological studies have found that metformin has a positive effect on the prevention and treatment of endometrial cancer, and a large number of basic and clinical studies have supported this theory, indicating that metformin may become the new treatment for patients with endometrial cancer, especially with advanced and recurrent endometrial cancer, and endometrial dysplasia.

Key words:Endometrial neoplasms,Metformin,Diabetes mellitus,Insulin resistance

赵小玲, 孔为民. 二甲双胍在子宫内膜癌中的基础与临床研究现状[J]. 国际肿瘤学杂志, 2020, 47(7): 440-443.

Zhao Xiaoling, Kong Weimin. Current status of basic and clinical research on metformin in endometrial cancer[J]. Journal of International Oncology, 2020, 47(7): 440-443.

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