二甲双胍在非霍奇金淋巴瘤中的研究进展

国际肿瘤学杂志››2022,Vol. 49››Issue (7): 436-440.doi:10.3760/cma.j.cn371439-20220414-00083

二甲双胍在非霍奇金淋巴瘤中的研究进展

王柳雪¹, 席晓平¹, 刘静静¹, 沈国民², 杨海平¹()

1.河南科技大学临床医学院,河南科技大学第一附属医院血液科,洛阳 471003
2.河南科技大学基础医学院,河南省血栓与止血国际联合实验室,洛阳 471003

收稿日期:2022-04-14修回日期:2022-05-25出版日期:2022-07-08发布日期:2022-09-19
通讯作者:杨海平 E-mail:13938820189@163.com
基金资助:
北京医卫健康公益基金会医学betway必威亚洲基金(YWJKJJHKYJJ-B182063)

Research progress of metformin in non-Hodgkin lymphoma

Wang Liuxue¹, Xi Xiaoping¹, Liu Jingjing¹, Shen Guomin², Yang Haiping¹()

1. Department of Hematology, First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China
2. School of Basic Medical Science, Henan University of Science and Technology, Henan International Joint Laboratory of Thrombosis and Hemostasis, Luoyang 471003, China

Received:2022-04-14Revised:2022-05-25Online:2022-07-08Published:2022-09-19
Contact:Yang Haiping E-mail:13938820189@163.com
Supported by:
Medical Science Research Fund of Beijing Medical and Health Foundation(YWJKJJHKYJJ-B182063)

摘要/Abstract

摘要：

临床前研究表明腺苷酸活化蛋白激酶（AMPK）激活剂二甲双胍可以抑制淋巴瘤细胞的生长,不影响正常淋巴细胞的功能,同时可促进淋巴瘤细胞凋亡,改善肿瘤免疫环境。临床研究表明二甲双胍用于初治及维持治疗均可以提高非霍奇金淋巴瘤（NHL）化疗疗效,改善预后;通过对糖代谢的影响,改善血糖水平,减少类固醇糖尿病的发生。二甲双胍抗NHL的主要分子机制包括激活肿瘤细胞内AMPK,抑制哺乳动物雷帕霉素靶蛋白信号、抑制关键的胆固醇合成、改善葡萄糖代谢、增强高细胞毒性T淋巴细胞活性等。目前研究显示,二甲双胍可能成为NHL治疗的一种新策略。

关键词:二甲双胍,淋巴瘤,非霍奇金,糖皮质激素类,腺苷酸活化蛋白激酶

Abstract:

Preclinical studies have shown that metformin, an activator of AMP-activated protein kinase （AMPK）, can inhibit the growth of lymphoma cells without affecting the function of normal lymphocytes, promote the apoptosis of lymphoma cells and improve the tumor immune environment. Clinical studies have shown that metformin can improve the efficacy of chemotherapy and prognosis of non-Hodgkin lymphoma （NHL）. Through the influence on glucose metabolism, it can improve blood glucose level and reduce the incidence of steroid diabetes. The main molecular mechanisms of metformin against NHL include activating AMPK in tumor cells, inhibiting mammalian target of rapamycin signal, inhibiting key cholesterol synthesis, improving glucose metabolism, enhancing highly cytotoxic T lymphocyte （CTL） activity and so on. Current research shows that metformin may become a new strategy for the treatment of NHL.

Key words:Metformin,Lymphoma, non-Hodgkin,Glucocorticoids,AMP-activated protein kinase

王柳雪, 席晓平, 刘静静, 沈国民, 杨海平. 二甲双胍在非霍奇金淋巴瘤中的研究进展[J]. 国际肿瘤学杂志, 2022, 49(7): 436-440.

Wang Liuxue, Xi Xiaoping, Liu Jingjing, Shen Guomin, Yang Haiping. Research progress of metformin in non-Hodgkin lymphoma[J]. Journal of International Oncology, 2022, 49(7): 436-440.

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